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Abstract: | Mid-infrared quantum cascade laser spectroscopy is used to noninvasively predict blood glucose concentrations of three healthy human subjects in vivo. We utilize a hollow-core fiber based optical setup for light delivery and collection along with a broadly tunable quantum cascade laser to obtain spectra from human subjects and use standard chemo-metric techniques (namely partial least squares regression) for prediction analysis. Throughout a glucose concentration range of 80-160 mg/dL, we achieve clinically accurate predictions 84% of the time, on average. This work opens a new path to a noninvasive in vivo glucose sensor that would benefit the lives of hundreds of millions of diabetics worldwide. |
Publication Date: | 23-Jun-2014 |
Electronic Publication Date: | 23-Jun-2014 |
Citation: | Liakat, S, Bors, KA, Xu, L, Woods, CM, Doyle, J, Gmachl, CF. (2014). Noninvasive in vivo glucose sensing on human subjects using mid-infrared light. Biomedical Optics Express, 5 (2397 - 2404. doi:10.1364/BOE.5.002397 |
DOI: | doi:10.1364/BOE.5.002397 |
Pages: | 2397 - 2404 |
Type of Material: | Journal Article |
Journal/Proceeding Title: | Biomedical Optics Express |
Version: | Final published version. Article is made available in OAR by the publisher's permission or policy. |
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