Skip to main content

Noninvasive in vivo glucose sensing on human subjects using mid-infrared light

Author(s): Liakat, S; Bors, KA; Xu, L; Woods, CM; Doyle, J; et al

To refer to this page use:
Abstract: Mid-infrared quantum cascade laser spectroscopy is used to noninvasively predict blood glucose concentrations of three healthy human subjects in vivo. We utilize a hollow-core fiber based optical setup for light delivery and collection along with a broadly tunable quantum cascade laser to obtain spectra from human subjects and use standard chemo-metric techniques (namely partial least squares regression) for prediction analysis. Throughout a glucose concentration range of 80-160 mg/dL, we achieve clinically accurate predictions 84% of the time, on average. This work opens a new path to a noninvasive in vivo glucose sensor that would benefit the lives of hundreds of millions of diabetics worldwide.
Publication Date: 23-Jun-2014
Electronic Publication Date: 23-Jun-2014
Citation: Liakat, S, Bors, KA, Xu, L, Woods, CM, Doyle, J, Gmachl, CF. (2014). Noninvasive in vivo glucose sensing on human subjects using mid-infrared light. Biomedical Optics Express, 5 (2397 - 2404. doi:10.1364/BOE.5.002397
DOI: doi:10.1364/BOE.5.002397
Pages: 2397 - 2404
Type of Material: Journal Article
Journal/Proceeding Title: Biomedical Optics Express
Version: Final published version. Article is made available in OAR by the publisher's permission or policy.

Items in OAR@Princeton are protected by copyright, with all rights reserved, unless otherwise indicated.