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How Can Vaccines Against Influenza and Other Viral Diseases Be Made More Effective?

Author(s): Nara, Peter L.; Tobin, Gregory J.; Chaudhuri, A. Ray; Trujillo, Jessie D.; Lin, George; et al

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Abstract: A large fraction of the world’s most widespread and problematic pathogens, such as the influenza virus, seem to persist in nature by evading host immune responses by inducing immunity to genetically and phenotypically plastic epitopes (aka antigenic variation). The more recent re-emergence of pandemic influenza A/ H1N1 and avian H5N1 viruses has called attention to the urgent need for more effective influenza vaccines. Developing such vaccines will require more than just moving from an egg-based to a tissueculture–based manufacturing process. It will also require a new conceptual understanding of pathogen–host interactions, as well as new approaches and technologies to circumvent immune evasion by pathogens capable of more genetic variation. Here, we discuss these challenges, focusing on some potentially fruitful directions for future research.
Publication Date: 21-Dec-2010
Electronic Publication Date: 21-Dec-2010
Citation: Nara, Peter L., Tobin, Gregory J., Chaudhuri, A. Ray, Trujillo, Jessie D., Lin, George, Cho, Michael W., Levin, Simon A., Ndifon, Wilfred, Wingreen, Ned S. (2010). How Can Vaccines Against Influenza and Other Viral Diseases Be Made More Effective?. PLoS Biology, 8 (12), e1000571 - e1000571. doi:10.1371/journal.pbio.1000571
DOI: doi:10.1371/journal.pbio.1000571
EISSN: 1545-7885
Pages: e1000571 - e1000571
Type of Material: Journal Article
Journal/Proceeding Title: PLoS Biology
Version: Final published version. This is an open access article.

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