Integrated Genomic Characterization of Pancreatic Ductal Adenocarcinoma.
Author(s): Cancer Genome Atlas Research Network. Electronic address: andrew_aguirre@dfci.harvard.edu; Cancer Genome Atlas Research Network; Raphael, Benjamin
DownloadTo refer to this page use:
http://arks.princeton.edu/ark:/88435/pr1653x
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Cancer Genome Atlas Research Network. Electronic address: andrew_aguirre@dfci.harvard.edu | - |
dc.contributor.author | Cancer Genome Atlas Research Network | - |
dc.contributor.author | Raphael, Benjamin | - |
dc.date.accessioned | 2021-10-08T19:47:02Z | - |
dc.date.available | 2021-10-08T19:47:02Z | - |
dc.date.issued | 2017-08 | en_US |
dc.identifier.citation | Cancer Genome Atlas Research Network. Electronic address: andrew_aguirre@dfci.harvard.edu, Cancer Genome Atlas Research Network. (2017). Integrated Genomic Characterization of Pancreatic Ductal Adenocarcinoma.. Cancer cell, 32 (2), 185 - 203.e13. doi:10.1016/j.ccell.2017.07.007 | en_US |
dc.identifier.issn | 1535-6108 | - |
dc.identifier.uri | http://arks.princeton.edu/ark:/88435/pr1653x | - |
dc.description.abstract | We performed integrated genomic, transcriptomic, and proteomic profiling of 150 pancreatic ductal adenocarcinoma (PDAC) specimens, including samples with characteristic low neoplastic cellularity. Deep whole-exome sequencing revealed recurrent somatic mutations in KRAS, TP53, CDKN2A, SMAD4, RNF43, ARID1A, TGFβR2, GNAS, RREB1, and PBRM1. KRAS wild-type tumors harbored alterations in other oncogenic drivers, including GNAS, BRAF, CTNNB1, and additional RAS pathway genes. A subset of tumors harbored multiple KRAS mutations, with some showing evidence of biallelic mutations. Protein profiling identified a favorable prognosis subset with low epithelial-mesenchymal transition and high MTOR pathway scores. Associations of non-coding RNAs with tumor-specific mRNA subtypes were also identified. Our integrated multi-platform analysis reveals a complex molecular landscape of PDAC and provides a roadmap for precision medicine. | en_US |
dc.format.extent | 185 - 203.e13 | en_US |
dc.language | eng | en_US |
dc.language.iso | en_US | en_US |
dc.relation.ispartof | Cancer cell | en_US |
dc.rights | Final published version. This is an open access article. | en_US |
dc.title | Integrated Genomic Characterization of Pancreatic Ductal Adenocarcinoma. | en_US |
dc.type | Journal Article | en_US |
dc.identifier.doi | doi:10.1016/j.ccell.2017.07.007 | - |
dc.identifier.eissn | 1878-3686 | - |
pu.type.symplectic | http://www.symplectic.co.uk/publications/atom-terms/1.0/journal-article | en_US |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
IntegratedGenomicPancreaticDuctalAdenocarcinoma.pdf | 23.03 MB | Adobe PDF | View/Download |
Items in OAR@Princeton are protected by copyright, with all rights reserved, unless otherwise indicated.