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The Coevolution of Virulence: Tolerance in Perspective

Author(s): Little, Tom J.; Shuker, David M.; Colegrave, Nick; Day, Troy; Graham, Andrea L.

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Abstract: Coevolutionary interactions, such as those between host and parasite, predator and prey, or plant and pollinator, evolve subject to the genes of both interactors. It is clear, for example, that the evolution of pollination strategies can only be understood with knowledge of both the pollinator and the pollinated. Studies of the evolution of virulence, the reduction in host fitness due to infection, have nonetheless tended to focus on parasite evolution. Host-centric approaches have also been proposed—for example, under the rubric of ‘‘tolerance’’, the ability of hosts to minimize virulence without necessarily minimizing parasite density. Within the tolerance framework, however, there is room for more comprehensive measures of host fitness traits, and for fuller consideration of the consequences of coevolution. For example, the evolution of tolerance can result in changed selection on parasite populations, which should provoke parasite evolution despite the fact that tolerance is not directly antagonistic to parasite fitness. As a result, consideration of the potential for parasite counteradaptation to host tolerance—whether evolved or medially manipulated—is essential to the emergence of a cohesive theory of biotic partnerships and robust disease control strategies.
Publication Date: 9-Sep-2010
Electronic Publication Date: 9-Sep-2010
Citation: Little, Tom J., Shuker, David M., Colegrave, Nick, Day, Troy, Graham, Andrea L. (2010). The Coevolution of Virulence: Tolerance in Perspective. PLoS Pathogens, 6 (9), e1001006 - e1001006. doi:10.1371/journal.ppat.1001006
DOI: doi:10.1371/journal.ppat.1001006
EISSN: 1553-7374
Pages: e1001006 - e1001006
Type of Material: Journal Article
Journal/Proceeding Title: PLoS Pathogens
Version: Final published version. This is an open access article.

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