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Avian influenza H5N1 viral and bird migration networks in Asia

Author(s): Tian, Huaiyu; Zhou, Sen; Dong, Lu; Van Boeckel, Thomas P.; Cui, Yujun; et al

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Abstract: The spatial spread of the highly pathogenic avian influenza virus H5N1 and its long-term persistence in Asia have resulted in avian influenza panzootics and enormous economic losses in the poultry sector. However, an understanding of the regional long-distance transmission and seasonal patterns of the virus is still lacking. In this study, we present a phylogeographic approach to reconstruct the viral migration network. We show that within each wild fowl migratory flyway, the timing of H5N1 outbreaks and viral migrations are closely associated, but little viral transmission was observed between the flyways. The bird migration network is shown to better reflect the observed viral gene sequence data than other networks and contributes to seasonal H5N1 epidemics in local regions and its large-scale transmission along flyways. These findings have potentially far-reaching consequences, improving our understanding of how bird migration drives the periodic reemergence of H5N1 in Asia.
Publication Date: 6-Jan-2015
Electronic Publication Date: 22-Dec-2014
Citation: Tian, Huaiyu, Zhou, Sen, Dong, Lu, Van Boeckel, Thomas P., Cui, Yujun, Newman, Scott H, Takekawa, John Y., Prosser, Diann J., Xiao, Xiangming, Wu, Yarong, Cazelles, Bernard, Huang, Shanqian, Yang, Ruifu, Grenfell, Bryan T., Xu, Bing. (2015). Avian influenza H5N1 viral and bird migration networks in Asia. Proceedings of the National Academy of Sciences, 112 (1), 172 - 177. doi:10.1073/pnas.1405216112
DOI: doi:10.1073/pnas.1405216112
ISSN: 0027-8424
EISSN: 1091-6490
Pages: 172 - 177
Type of Material: Journal Article
Journal/Proceeding Title: Proceedings of the National Academy of Sciences
Version: Final published version. This is an open access article.

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