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Synthesizing epidemiological and economic optima for control of immunizing infections

Author(s): Klepac, Petra; Laxminarayan, R.; Grenfell, Bryan T.

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Abstract: Epidemic theory predicts that the vaccination threshold required to interrupt local transmission of an immunizing infection like measles depends only on the basic reproductive number ℛ0 and hence transmission rates. When the search for optimal strategies is expanded to incorporate economic constraints, the optimum for disease control in a single population is determined by relative costs of infection and control, rather than transmission rates. Adding a spatial dimension, which precludes local elimination unless it can be achieved globally, can reduce or increase optimal vaccination levels depending on the balance of costs and benefits. For weakly coupled populations, local optimal strategies agree with the global cost-effective strategy; however, asymmetries in costs can lead to divergent control optima in more strongly coupled systems—in particular, strong regional differences in costs of vaccination can preclude local elimination even when elimination is locally optimal. Under certain conditions, it is locally optimal to share vaccination resources with other populations.
Publication Date: 23-Aug-2011
Electronic Publication Date: 8-Aug-2011
Citation: Klepac, P., Laxminarayan, R., Grenfell, B.T. (2011). Synthesizing epidemiological and economic optima for control of immunizing infections. Proceedings of the National Academy of Sciences, 108 (34), 14366 - 14370. doi:10.1073/pnas.1101694108
DOI: doi:10.1073/pnas.1101694108
ISSN: 0027-8424
EISSN: 1091-6490
Pages: 14366 - 14370
Type of Material: Journal Article
Journal/Proceeding Title: Proceedings of the National Academy of Sciences
Version: Final published version. Article is made available in OAR by the publisher's permission or policy.

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