Ultrasensitive Ebola virus antigen detection via a nanoantenna-array biosensing platform

Abstract

We have developed a plasmonic nanoantenna-array-based biosensor platform for the detection of Ebola virus (EBOV) antigen – soluble glycoprotein (sGP) – that is over 10,000-fold more sensitive than conventional enzyme-linked immunosorbent assays (ELISA). The sensor maximizes the excitation laser absorption efficiency on-chip to 95%, and has demonstrated an analytical sensitivity of 95.8%. These results combined highlight the significant potential of nanostructured biosensors in ultrasensitive detection of pathogens.