Skip to main content

The potential impact of coinfection on antimicrobial chemotherapy and drug resistance

Author(s): Birger, Ruthie B.; Kouyos, Roger D.; Cohen, Ted; Griffiths, Emily C.; Huijben, Silvie; et al

To refer to this page use:
Abstract: Across a range of pathogens, resistance to chemotherapy is a growing problem in both public health and animal health. Despite the ubiquity of coinfection, and its potential effects on within-host biology, the role played by coinfecting pathogens on the evolution of resistance and efficacy of antimicrobial chemotherapy is rarely considered. In this review, we provide an overview of the mechanisms of interaction of coinfecting pathogens, ranging from immune modulation and resource modulation, to drug interactions. We discuss their potential implications for the evolution of resistance, providing evidence in the rare cases where it is available. Overall, our review indicates that the impact of coinfection has the potential to be considerable, suggesting that this should be taken into account when designing antimicrobial drug treatments.
Publication Date: Sep-2015
Citation: Birger, Ruthie B., Kouyos, Roger D., Cohen, Ted, Griffiths, Emily C., Huijben, Silvie, Mina, Michael J., Volkova, Victoriya, Grenfell, Bryan T., Metcalf, C. Jessica E. (2015). The potential impact of coinfection on antimicrobial chemotherapy and drug resistance. Trends in Microbiology, 23 (9), 537 - 544. doi:10.1016/j.tim.2015.05.002
DOI: doi:10.1016/j.tim.2015.05.002
ISSN: 0966-842X
Pages: 537 - 544
Type of Material: Journal Article
Journal/Proceeding Title: Trends in Microbiology
Version: Author's manuscript

Items in OAR@Princeton are protected by copyright, with all rights reserved, unless otherwise indicated.