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GIANT 2.0: genome-scale integrated analysis of gene networks in tissues

Author(s): Wong, Aaron K; Krishnan, Arjun; Troyanskaya, Olga G

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dc.contributor.authorWong, Aaron K-
dc.contributor.authorKrishnan, Arjun-
dc.contributor.authorTroyanskaya, Olga G-
dc.identifier.citationWong, Aaron K., Arjun Krishnan, and Olga G. Troyanskaya. "GIANT 2.0: genome-scale integrated analysis of gene networks in tissues." Nucleic Acids Research 46, no. W1 (2018): W65-W70. doi:10.1093/nar/gky408en_US
dc.description.abstractGIANT2 (Genome-wide Integrated Analysis of gene Networks in Tissues) is an interactive web server that enables biomedical researchers to analyze their proteins and pathways of interest and generate hypotheses in the context of genome-scale functional maps of human tissues. The precise actions of genes are frequently dependent on their tissue context, yet direct assay of tissue-specific protein function and interactions remains infeasible in many normal human tissues and cell-types. With GIANT2, researchers can explore predicted tissue-specific functional roles of genes and reveal changes in those roles across tissues, all through interactive multi-network visualizations and analyses. Additionally, the NetWAS approach available through the server uses tissue-specific/cell-type networks predicted by GIANT2 to re-prioritize statistical associations from GWAS studies and identify disease-associated genes. GIANT2 predicts tissue-specific interactions by integrating diverse functional genomics data from now over 61 400 experiments for 283 diverse tissues and cell-types. GIANT2 does not require any registration or installation and is freely available for use at
dc.format.extentW65 - W70en_US
dc.relation.ispartofNucleic Acids Researchen_US
dc.rightsFinal published version. This is an open access article.en_US
dc.titleGIANT 2.0: genome-scale integrated analysis of gene networks in tissuesen_US
dc.typeJournal Articleen_US

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