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Genetic effects on gene expression across human tissues

Author(s): Aguet, François; Brown, Andrew A.; Castel, Stephane E.; Davis, Joe R.; He, Yuan; et al

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dc.contributor.authorAguet, François-
dc.contributor.authorBrown, Andrew A.-
dc.contributor.authorCastel, Stephane E.-
dc.contributor.authorDavis, Joe R.-
dc.contributor.authorHe, Yuan-
dc.contributor.authorJo, Brian-
dc.contributor.authorMohammadi, Pejman-
dc.contributor.authorPark, YoSon-
dc.contributor.authorParsana, Princy-
dc.contributor.authorSegrè, Ayellet V.-
dc.contributor.authorStrober, Benjamin J.-
dc.contributor.authorZappala, Zachary-
dc.contributor.authorCummings, Beryl B.-
dc.contributor.authorGelfand, Ellen T.-
dc.contributor.authorHadley, Kane-
dc.contributor.authorHuang, Katherine H.-
dc.contributor.authorLek, Monkol-
dc.contributor.authorLi, Xiao-
dc.contributor.authorNedzel, Jared L.-
dc.contributor.authorNguyen, Duyen Y.-
dc.contributor.authorNoble, Michael S.-
dc.contributor.authorSullivan, Timothy J.-
dc.contributor.authorTukiainen, Taru-
dc.contributor.authorMacArthur, Daniel G.-
dc.contributor.authorGetz, Gad-
dc.contributor.authorAddington, Anjene-
dc.contributor.authorGuan, Ping-
dc.contributor.authorKoester, Susan-
dc.contributor.authorLittle, A. Roger-
dc.contributor.authorLockhart, Nicole C.-
dc.contributor.authorMoore, Helen M.-
dc.contributor.authorRao, Abhi-
dc.contributor.authorStruewing, Jeffery P.-
dc.contributor.authorVolpi, Simona-
dc.contributor.authorBrigham, Lori E.-
dc.contributor.authorHasz, Richard-
dc.contributor.authorHunter, Marcus-
dc.contributor.authorJohns, Christopher-
dc.contributor.authorJohnson, Mark-
dc.contributor.authorKopen, Gene-
dc.contributor.authorLeinweber, William F.-
dc.contributor.authorLonsdale, John T.-
dc.contributor.authorMcDonald, Alisa-
dc.contributor.authorMestichelli, Bernadette-
dc.contributor.authorMyer, Kevin-
dc.contributor.authorRoe, Bryan-
dc.contributor.authorSalvatore, Michael-
dc.contributor.authorShad, Saboor-
dc.contributor.authorThomas, Jeffrey A.-
dc.contributor.authorWalters, Gary-
dc.contributor.authorWashington, Michael-
dc.contributor.authorWheeler, Joseph-
dc.contributor.authorBridge, Jason-
dc.contributor.authorFoster, Barbara A.-
dc.contributor.authorGillard, Bryan M.-
dc.contributor.authorKarasik, Ellen-
dc.contributor.authorKumar, Rachna-
dc.contributor.authorMiklos, Mark-
dc.contributor.authorMoser, Michael T.-
dc.contributor.authorJewell, Scott D.-
dc.contributor.authorMontroy, Robert G.-
dc.contributor.authorRohrer, Daniel C.-
dc.contributor.authorValley, Dana-
dc.contributor.authorMash, Deborah C.-
dc.contributor.authorDavis, David A.-
dc.contributor.authorSobin, Leslie-
dc.contributor.authorBarcus, Mary E.-
dc.contributor.authorBranton, Philip A.-
dc.contributor.authorAbell, Nathan S.-
dc.contributor.authorBalliu, Brunilda-
dc.contributor.authorDelaneau, Olivier-
dc.contributor.authorFrésard, Laure-
dc.contributor.authorGamazon, Eric R.-
dc.contributor.authorGarrido-Martín, Diego-
dc.contributor.authorGewirtz, Ariel D.H.-
dc.contributor.authorGliner, Genna-
dc.contributor.authorGloudemans, Michael J.-
dc.contributor.authorHan, Buhm-
dc.contributor.authorHe, Amy Z.-
dc.contributor.authorHormozdiari, Farhad-
dc.contributor.authorLi, Xin-
dc.contributor.authorLiu, Boxiang-
dc.contributor.authorKang, Eun Yong-
dc.contributor.authorMcDowell, Ian C.-
dc.contributor.authorOngen, Halit-
dc.contributor.authorPalowitch, John J.-
dc.contributor.authorPeterson, Christine B.-
dc.contributor.authorQuon, Gerald-
dc.contributor.authorRipke, Stephan-
dc.contributor.authorSaha, Ashis-
dc.contributor.authorShabalin, Andrey A.-
dc.contributor.authorShimko, Tyler C.-
dc.contributor.authorSul, Jae Hoon-
dc.contributor.authorTeran, Nicole A.-
dc.contributor.authorTsang, Emily K.-
dc.contributor.authorZhang, Hailei-
dc.contributor.authorZhou, Yi-Hui-
dc.contributor.authorBustamante, Carlos D.-
dc.contributor.authorCox, Nancy J.-
dc.contributor.authorGuigó, Roderic-
dc.contributor.authorKellis, Manolis-
dc.contributor.authorMcCarthy, Mark I.-
dc.contributor.authorConrad, Donald F.-
dc.contributor.authorEskin, Eleazar-
dc.contributor.authorLi, Gen-
dc.contributor.authorNobel, Andrew B.-
dc.contributor.authorSabatti, Chiara-
dc.contributor.authorStranger, Barbara E.-
dc.contributor.authorWen, Xiaoquan-
dc.contributor.authorWright, Fred A.-
dc.contributor.authorArdlie, Kristin G.-
dc.contributor.authorDermitzakis, Emmanouil T.-
dc.contributor.authorLappalainen, Tuuli-
dc.contributor.authorAguet, François-
dc.contributor.authorArdlie, Kristin G.-
dc.contributor.authorCummings, Beryl B.-
dc.contributor.authorGelfand, Ellen T.-
dc.contributor.authorGetz, Gad-
dc.contributor.authorHadley, Kane-
dc.contributor.authorHandsaker, Robert E.-
dc.contributor.authorHuang, Katherine H.-
dc.contributor.authorKashin, Seva-
dc.contributor.authorKarczewski, Konrad J.-
dc.contributor.authorLek, Monkol-
dc.contributor.authorLi, Xiao-
dc.contributor.authorMacArthur, Daniel G.-
dc.contributor.authorNedzel, Jared L.-
dc.contributor.authorNguyen, Duyen T.-
dc.contributor.authorNoble, Michael S.-
dc.contributor.authorSegrè, Ayellet V.-
dc.contributor.authorTrowbridge, Casandra A.-
dc.contributor.authorTukiainen, Taru-
dc.contributor.authorAbell, Nathan S.-
dc.contributor.authorBalliu, Brunilda-
dc.contributor.authorBarshir, Ruth-
dc.contributor.authorBasha, Omer-
dc.contributor.authorBattle, Alexis-
dc.contributor.authorBogu, Gireesh K.-
dc.contributor.authorBrown, Andrew-
dc.contributor.authorBrown, Christopher D.-
dc.contributor.authorCastel, Stephane E.-
dc.contributor.authorChen, Lin S.-
dc.contributor.authorChiang, Colby-
dc.contributor.authorConrad, Donald F.-
dc.contributor.authorCox, Nancy J.-
dc.contributor.authorDamani, Farhan N.-
dc.contributor.authorDavis, Joe R.-
dc.contributor.authorDelaneau, Olivier-
dc.contributor.authorDermitzakis, Emmanouil T.-
dc.contributor.authorEngelhardt, Barbara E.-
dc.contributor.authorEskin, Eleazar-
dc.contributor.authorFerreira, Pedro G.-
dc.contributor.authorFrésard, Laure-
dc.contributor.authorGamazon, Eric R.-
dc.contributor.authorGarrido-Martín, Diego-
dc.contributor.authorGewirtz, Ariel D.H.-
dc.contributor.authorGliner, Genna-
dc.contributor.authorGloudemans, Michael J.-
dc.contributor.authorGuigo, Roderic-
dc.contributor.authorHall, Ira M.-
dc.contributor.authorHan, Buhm-
dc.contributor.authorHe, Yuan-
dc.contributor.authorHormozdiari, Farhad-
dc.contributor.authorHowald, Cedric-
dc.contributor.authorKyung Im, Hae-
dc.contributor.authorJo, Brian-
dc.contributor.authorYong Kang, Eun-
dc.contributor.authorKim, Yungil-
dc.contributor.authorKim-Hellmuth, Sarah-
dc.contributor.authorLappalainen, Tuuli-
dc.contributor.authorLi, Gen-
dc.contributor.authorLi, Xin-
dc.contributor.authorLiu, Boxiang-
dc.contributor.authorMangul, Serghei-
dc.contributor.authorMcCarthy, Mark I.-
dc.contributor.authorMcDowell, Ian C.-
dc.contributor.authorMohammadi, Pejman-
dc.contributor.authorMonlong, Jean-
dc.contributor.authorMontgomery, Stephen B.-
dc.contributor.authorMuñoz-Aguirre, Manuel-
dc.contributor.authorNdungu, Anne W.-
dc.contributor.authorNicolae, Dan L.-
dc.contributor.authorNobel, Andrew B.-
dc.contributor.authorOliva, Meritxell-
dc.contributor.authorOngen, Halit-
dc.contributor.authorPalowitch, John J.-
dc.contributor.authorPanousis, Nikolaos-
dc.contributor.authorPapasaikas, Panagiotis-
dc.contributor.authorPark, YoSon-
dc.contributor.authorParsana, Princy-
dc.contributor.authorPayne, Anthony J.-
dc.contributor.authorPeterson, Christine B.-
dc.contributor.authorQuan, Jie-
dc.contributor.authorReverter, Ferran-
dc.contributor.authorSabatti, Chiara-
dc.contributor.authorSaha, Ashis-
dc.contributor.authorSammeth, Michael-
dc.contributor.authorScott, Alexandra J.-
dc.contributor.authorShabalin, Andrey A.-
dc.contributor.authorSodaei, Reza-
dc.contributor.authorStephens, Matthew-
dc.contributor.authorStranger, Barbara E.-
dc.contributor.authorStrober, Benjamin J.-
dc.contributor.authorSul, Jae Hoon-
dc.contributor.authorTsang, Emily K.-
dc.contributor.authorUrbut, Sarah-
dc.contributor.authorvan de Bunt, Martijn-
dc.contributor.authorWang, Gao-
dc.contributor.authorWen, Xiaoquan-
dc.contributor.authorWright, Fred A.-
dc.contributor.authorXi, Hualin S.-
dc.contributor.authorYeger-Lotem, Esti-
dc.contributor.authorZappala, Zachary-
dc.contributor.authorZaugg, Judith B.-
dc.contributor.authorZhou, Yi-Hui-
dc.contributor.authorAkey, Joshua M.-
dc.contributor.authorBates, Daniel-
dc.contributor.authorChan, Joanne-
dc.contributor.authorChen, Lin S.-
dc.contributor.authorClaussnitzer, Melina-
dc.contributor.authorDemanelis, Kathryn-
dc.contributor.authorDiegel, Morgan-
dc.contributor.authorDoherty, Jennifer A.-
dc.contributor.authorFeinberg, Andrew P.-
dc.contributor.authorFernando, Marian S.-
dc.contributor.authorHalow, Jessica-
dc.contributor.authorHansen, Kasper D.-
dc.contributor.authorHaugen, Eric-
dc.contributor.authorHickey, Peter F.-
dc.contributor.authorHou, Lei-
dc.contributor.authorJasmine, Farzana-
dc.contributor.authorJian, Ruiqi-
dc.contributor.authorJiang, Lihua-
dc.contributor.authorJohnson, Audra-
dc.contributor.authorKaul, Rajinder-
dc.contributor.authorKellis, Manolis-
dc.contributor.authorKibriya, Muhammad G.-
dc.contributor.authorLee, Kristen-
dc.contributor.authorBilly Li, Jin-
dc.contributor.authorLi, Qin-
dc.contributor.authorLi, Xiao-
dc.contributor.authorLin, Jessica-
dc.contributor.authorLin, Shin-
dc.contributor.authorLinder, Sandra-
dc.contributor.authorLinke, Caroline-
dc.contributor.authorLiu, Yaping-
dc.contributor.authorMaurano, Matthew T.-
dc.contributor.authorMolinie, Benoit-
dc.contributor.authorMontgomery, Stephen B.-
dc.contributor.authorNelson, Jemma-
dc.contributor.authorNeri, Fidencio J.-
dc.contributor.authorOliva, Meritxell-
dc.contributor.authorPark, Yongjin-
dc.contributor.authorPierce, Brandon L.-
dc.contributor.authorRinaldi, Nicola J.-
dc.contributor.authorRizzardi, Lindsay F.-
dc.contributor.authorSandstrom, Richard-
dc.contributor.authorSkol, Andrew-
dc.contributor.authorSmith, Kevin S.-
dc.contributor.authorSnyder, Michael P.-
dc.contributor.authorStamatoyannopoulos, John-
dc.contributor.authorStranger, Barbara E.-
dc.contributor.authorTang, Hua-
dc.contributor.authorTsang, Emily K.-
dc.contributor.authorWang, Li-
dc.contributor.authorWang, Meng-
dc.contributor.authorVan Wittenberghe, Nicholas-
dc.contributor.authorWu, Fan-
dc.contributor.authorZhang, Rui-
dc.contributor.authorNierras, Concepcion R.-
dc.contributor.authorBranton, Philip A.-
dc.contributor.authorCarithers, Latarsha J.-
dc.contributor.authorGuan, Ping-
dc.contributor.authorMoore, Helen M.-
dc.contributor.authorRao, Abhi-
dc.contributor.authorVaught, Jimmie B.-
dc.contributor.authorGould, Sarah E.-
dc.contributor.authorLockart, Nicole C.-
dc.contributor.authorMartin, Casey-
dc.contributor.authorStruewing, Jeffery P.-
dc.contributor.authorVolpi, Simona-
dc.contributor.authorAddington, Anjene M.-
dc.contributor.authorKoester, Susan E.-
dc.contributor.authorLittle, A. Roger-
dc.contributor.authorBrigham, Lori E.-
dc.contributor.authorHasz, Richard-
dc.contributor.authorHunter, Marcus-
dc.contributor.authorJohns, Christopher-
dc.contributor.authorJohnson, Mark-
dc.contributor.authorKopen, Gene-
dc.contributor.authorLeinweber, William F.-
dc.contributor.authorLonsdale, John T.-
dc.contributor.authorMcDonald, Alisa-
dc.contributor.authorMestichelli, Bernadette-
dc.contributor.authorMyer, Kevin-
dc.contributor.authorRoe, Brian-
dc.contributor.authorSalvatore, Michael-
dc.contributor.authorShad, Saboor-
dc.contributor.authorThomas, Jeffrey A.-
dc.contributor.authorWalters, Gary-
dc.contributor.authorWashington, Michael-
dc.contributor.authorWheeler, Joseph-
dc.contributor.authorBridge, Jason-
dc.contributor.authorFoster, Barbara A.-
dc.contributor.authorGillard, Bryan M.-
dc.contributor.authorKarasik, Ellen-
dc.contributor.authorKumar, Rachna-
dc.contributor.authorMiklos, Mark-
dc.contributor.authorMoser, Michael T.-
dc.contributor.authorJewell, Scott D.-
dc.contributor.authorMontroy, Robert G.-
dc.contributor.authorRohrer, Daniel C.-
dc.contributor.authorValley, Dana R.-
dc.contributor.authorDavis, David A.-
dc.contributor.authorMash, Deborah C.-
dc.contributor.authorUndale, Anita H.-
dc.contributor.authorSmith, Anna M.-
dc.contributor.authorTabor, David E.-
dc.contributor.authorRoche, Nancy V.-
dc.contributor.authorMcLean, Jeffrey A.-
dc.contributor.authorVatanian, Negin-
dc.contributor.authorRobinson, Karna L.-
dc.contributor.authorSobin, Leslie-
dc.contributor.authorBarcus, Mary E.-
dc.contributor.authorValentino, Kimberly M.-
dc.contributor.authorQi, Liqun-
dc.contributor.authorHunter, Steven-
dc.contributor.authorHariharan, Pushpa-
dc.contributor.authorSingh, Shilpi-
dc.contributor.authorUm, Ki Sung-
dc.contributor.authorMatose, Takunda-
dc.contributor.authorTomaszewski, Maria M.-
dc.contributor.authorBarker, Laura K.-
dc.contributor.authorMosavel, Maghboeba-
dc.contributor.authorSiminoff, Laura A.-
dc.contributor.authorTraino, Heather M.-
dc.contributor.authorFlicek, Paul-
dc.contributor.authorJuettemann, Thomas-
dc.contributor.authorRuffier, Magali-
dc.contributor.authorSheppard, Dan-
dc.contributor.authorTaylor, Kieron-
dc.contributor.authorTrevanion, Stephen J.-
dc.contributor.authorZerbino, Daniel R.-
dc.contributor.authorCraft, Brian-
dc.contributor.authorGoldman, Mary-
dc.contributor.authorHaeussler, Maximilian-
dc.contributor.authorKent, W. James-
dc.contributor.authorLee, Christopher M.-
dc.contributor.authorPaten, Benedict-
dc.contributor.authorRosenbloom, Kate R.-
dc.contributor.authorVivian, John-
dc.contributor.authorZhu, Jingchun-
dc.date.accessioned2019-04-19T18:29:14Z-
dc.date.available2019-04-19T18:29:14Z-
dc.date.issued2017-10-11en_US
dc.identifier.citationAguet, François, Brown, Andrew A, Castel, Stephane E, Davis, Joe R, He, Yuan, Jo, Brian, Mohammadi, Pejman, Park, YoSon, Parsana, Princy, Segrè, Ayellet V, Strober, Benjamin J, Zappala, Zachary, Cummings, Beryl B, Gelfand, Ellen T, Hadley, Kane, Huang, Katherine H, Lek, Monkol, Li, Xiao, Nedzel, Jared L, Nguyen, Duyen Y, Noble, Michael S, Sullivan, Timothy J, Tukiainen, Taru, MacArthur, Daniel G, Getz, Gad, Addington, Anjene, Guan, Ping, Koester, Susan, Little, A Roger, Lockhart, Nicole C, Moore, Helen M, Rao, Abhi, Struewing, Jeffery P, Volpi, Simona, Brigham, Lori E, Hasz, Richard, Hunter, Marcus, Johns, Christopher, Johnson, Mark, Kopen, Gene, Leinweber, William F, Lonsdale, John T, McDonald, Alisa, Mestichelli, Bernadette, Myer, Kevin, Roe, Bryan, Salvatore, Michael, Shad, Saboor, Thomas, Jeffrey A, Walters, Gary, Washington, Michael, Wheeler, Joseph, Bridge, Jason, Foster, Barbara A, Gillard, Bryan M, Karasik, Ellen, Kumar, Rachna, Miklos, Mark, Moser, Michael T, Jewell, Scott D, Montroy, Robert G, Rohrer, Daniel C, Valley, Dana, Mash, Deborah C, Davis, David A, Sobin, Leslie, Barcus, Mary E, Branton, Philip A, Abell, Nathan S, Balliu, Brunilda, Delaneau, Olivier, Frésard, Laure, Gamazon, Eric R, Garrido-Martín, Diego, Gewirtz, Ariel DH, Gliner, Genna, Gloudemans, Michael J, Han, Buhm, He, Amy Z, Hormozdiari, Farhad, Li, Xin, Liu, Boxiang, Kang, Eun Yong, McDowell, Ian C, Ongen, Halit, Palowitch, John J, Peterson, Christine B, Quon, Gerald, Ripke, Stephan, Saha, Ashis, Shabalin, Andrey A, Shimko, Tyler C, Sul, Jae Hoon, Teran, Nicole A, Tsang, Emily K, Zhang, Hailei, Zhou, Yi-Hui, Bustamante, Carlos D, Cox, Nancy J, Guigó, Roderic, Kellis, Manolis, McCarthy, Mark I, Conrad, Donald F, Eskin, Eleazar, Li, Gen, Nobel, Andrew B, Sabatti, Chiara, Stranger, Barbara E, Wen, Xiaoquan, Wright, Fred A, Ardlie, Kristin G, Dermitzakis, Emmanouil T, Lappalainen, Tuuli, Aguet, François, Ardlie, Kristin G, Cummings, Beryl B, Gelfand, Ellen T, Getz, Gad, Hadley, Kane, Handsaker, Robert E, Huang, Katherine H, Kashin, Seva, Karczewski, Konrad J, Lek, Monkol, Li, Xiao, MacArthur, Daniel G, Nedzel, Jared L, Nguyen, Duyen T, Noble, Michael S, Segrè, Ayellet V, Trowbridge, Casandra A, Tukiainen, Taru, Abell, Nathan S, Balliu, Brunilda, Barshir, Ruth, Basha, Omer, Battle, Alexis, Bogu, Gireesh K, Brown, Andrew, Brown, Christopher D, Castel, Stephane E, Chen, Lin S, Chiang, Colby, Conrad, Donald F, Cox, Nancy J, Damani, Farhan N, Davis, Joe R, Delaneau, Olivier, Dermitzakis, Emmanouil T, Engelhardt, Barbara E, Eskin, Eleazar, Ferreira, Pedro G, Frésard, Laure, Gamazon, Eric R, Garrido-Martín, Diego, Gewirtz, Ariel DH, Gliner, Genna, Gloudemans, Michael J, Guigo, Roderic, Hall, Ira M, Han, Buhm, He, Yuan, Hormozdiari, Farhad, Howald, Cedric, Kyung Im, Hae, Jo, Brian, Yong Kang, Eun, Kim, Yungil, Kim-Hellmuth, Sarah, Lappalainen, Tuuli, Li, Gen, Li, Xin, Liu, Boxiang, Mangul, Serghei, McCarthy, Mark I, McDowell, Ian C, Mohammadi, Pejman, Monlong, Jean, Montgomery, Stephen B, Muñoz-Aguirre, Manuel, Ndungu, Anne W, Nicolae, Dan L, Nobel, Andrew B, Oliva, Meritxell, Ongen, Halit, Palowitch, John J, Panousis, Nikolaos, Papasaikas, Panagiotis, Park, YoSon, Parsana, Princy, Payne, Anthony J, Peterson, Christine B, Quan, Jie, Reverter, Ferran, Sabatti, Chiara, Saha, Ashis, Sammeth, Michael, Scott, Alexandra J, Shabalin, Andrey A, Sodaei, Reza, Stephens, Matthew, Stranger, Barbara E, Strober, Benjamin J, Sul, Jae Hoon, Tsang, Emily K, Urbut, Sarah, van de Bunt, Martijn, Wang, Gao, Wen, Xiaoquan, Wright, Fred A, Xi, Hualin S, Yeger-Lotem, Esti, Zappala, Zachary, Zaugg, Judith B, Zhou, Yi-Hui, Akey, Joshua M, Bates, Daniel, Chan, Joanne, Chen, Lin S, Claussnitzer, Melina, Demanelis, Kathryn, Diegel, Morgan, Doherty, Jennifer A, Feinberg, Andrew P, Fernando, Marian S, Halow, Jessica, Hansen, Kasper D, Haugen, Eric, Hickey, Peter F, Hou, Lei, Jasmine, Farzana, Jian, Ruiqi, Jiang, Lihua, Johnson, Audra, Kaul, Rajinder, Kellis, Manolis, Kibriya, Muhammad G, Lee, Kristen, Billy Li, Jin, Li, Qin, Li, Xiao, Lin, Jessica, Lin, Shin, Linder, Sandra, Linke, Caroline, Liu, Yaping, Maurano, Matthew T, Molinie, Benoit, Montgomery, Stephen B, Nelson, Jemma, Neri, Fidencio J, Oliva, Meritxell, Park, Yongjin, Pierce, Brandon L, Rinaldi, Nicola J, Rizzardi, Lindsay F, Sandstrom, Richard, Skol, Andrew, Smith, Kevin S, Snyder, Michael P, Stamatoyannopoulos, John, Stranger, Barbara E, Tang, Hua, Tsang, Emily K, Wang, Li, Wang, Meng, Van Wittenberghe, Nicholas, Wu, Fan, Zhang, Rui, Nierras, Concepcion R, Branton, Philip A, Carithers, Latarsha J, Guan, Ping, Moore, Helen M, Rao, Abhi, Vaught, Jimmie B, Gould, Sarah E, Lockart, Nicole C, Martin, Casey, Struewing, Jeffery P, Volpi, Simona, Addington, Anjene M, Koester, Susan E, Little, A Roger, Brigham, Lori E, Hasz, Richard, Hunter, Marcus, Johns, Christopher, Johnson, Mark, Kopen, Gene, Leinweber, William F, Lonsdale, John T, McDonald, Alisa, Mestichelli, Bernadette, Myer, Kevin, Roe, Brian, Salvatore, Michael, Shad, Saboor, Thomas, Jeffrey A, Walters, Gary, Washington, Michael, Wheeler, Joseph, Bridge, Jason, Foster, Barbara A, Gillard, Bryan M, Karasik, Ellen, Kumar, Rachna, Miklos, Mark, Moser, Michael T, Jewell, Scott D, Montroy, Robert G, Rohrer, Daniel C, Valley, Dana R, Davis, David A, Mash, Deborah C, Undale, Anita H, Smith, Anna M, Tabor, David E, Roche, Nancy V, McLean, Jeffrey A, Vatanian, Negin, Robinson, Karna L, Sobin, Leslie, Barcus, Mary E, Valentino, Kimberly M, Qi, Liqun, Hunter, Steven, Hariharan, Pushpa, Singh, Shilpi, Um, Ki Sung, Matose, Takunda, Tomaszewski, Maria M, Barker, Laura K, Mosavel, Maghboeba, Siminoff, Laura A, Traino, Heather M, Flicek, Paul, Juettemann, Thomas, Ruffier, Magali, Sheppard, Dan, Taylor, Kieron, Trevanion, Stephen J, Zerbino, Daniel R, Craft, Brian, Goldman, Mary, Haeussler, Maximilian, Kent, W James, Lee, Christopher M, Paten, Benedict, Rosenbloom, Kate R, Vivian, John, Zhu, Jingchun. (2017). Genetic effects on gene expression across human tissues. Nature, 550 (7675), 204 - 213. doi:10.1038/nature24277en_US
dc.identifier.issn0028-0836-
dc.identifier.urihttp://arks.princeton.edu/ark:/88435/pr1v99g-
dc.description.abstractCharacterization of the molecular function of the human genome and its variation across individuals is essential for identifying the cellular mechanisms that underlie human genetic traits and diseases. The Genotype-Tissue Expression (GTEx) project aims to characterize variation in gene expression levels across individuals and diverse tissues of the human body, many of which are not easily accessible. Here we describe genetic effects on gene expression levels across 44 human tissues. We find that local genetic variation affects gene expression levels for the majority of genes, and we further identify inter-chromosomal genetic effects for 93 genes and 112 loci. On the basis of the identified genetic effects, we characterize patterns of tissue specificity, compare local and distal effects, and evaluate the functional properties of the genetic effects. We also demonstrate that multi-tissue, multi-individual data can be used to identify genes and pathways affected by human disease-associated variation, enabling a mechanistic interpretation of gene regulation and the genetic basis of disease.en_US
dc.format.extent204 - 213en_US
dc.language.isoen_USen_US
dc.relation.ispartofNatureen_US
dc.rightsFinal published version. This is an open access article.en_US
dc.titleGenetic effects on gene expression across human tissuesen_US
dc.typeJournal Articleen_US
dc.identifier.doidoi:10.1038/nature24277-
dc.date.eissued2017-10-11en_US
dc.identifier.eissn1476-4687-
pu.type.symplectichttp://www.symplectic.co.uk/publications/atom-terms/1.0/journal-articleen_US

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