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Role of the Membrane for Mechanosensing by Tethered Channels

Author(s): Sabass, Benedikt; Stone, Howard A

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Abstract: Biologically important membrane channels are gated by force at attached tethers. Here, we generically characterize the nontrivial interplay of force, membrane tension, and channel deformations that can affect gating. A central finding is that minute conical channel deformation under force leads to significant energy release during opening. We also calculate channel-channel interactions and show that they can amplify the force sensitivity of tethered channels.
Publication Date: Jun-2016
Electronic Publication Date: 20-Jun-2016
Citation: Sabass, Benedikt, Stone, Howard A. (2016). Role of the Membrane for Mechanosensing by Tethered Channels. Physical Review Letters, 116 (25), 10.1103/PhysRevLett.116.258101
DOI: doi:10.1103/PhysRevLett.116.258101
ISSN: 0031-9007
EISSN: 1079-7114
Type of Material: Journal Article
Journal/Proceeding Title: Physical Review Letters
Version: Author's manuscript

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