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Role of the Membrane for Mechanosensing by Tethered Channels

Author(s): Sabass, Benedikt; Stone, Howard A

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dc.contributor.authorSabass, Benedikt-
dc.contributor.authorStone, Howard A-
dc.identifier.citationSabass, Benedikt, Stone, Howard A. (2016). Role of the Membrane for Mechanosensing by Tethered Channels. Physical Review Letters, 116 (25), 10.1103/PhysRevLett.116.258101en_US
dc.description.abstractBiologically important membrane channels are gated by force at attached tethers. Here, we generically characterize the nontrivial interplay of force, membrane tension, and channel deformations that can affect gating. A central finding is that minute conical channel deformation under force leads to significant energy release during opening. We also calculate channel-channel interactions and show that they can amplify the force sensitivity of tethered channels.en_US
dc.relation.ispartofPhysical Review Lettersen_US
dc.rightsAuthor's manuscripten_US
dc.titleRole of the Membrane for Mechanosensing by Tethered Channelsen_US
dc.typeJournal Articleen_US

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