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: a database of ciliate genome rearrangements

Author(s): Burns, Jonathan; Kukushkin, Denys; Lindblad, Kelsi; Chen, Xiao; Jonoska, Nataša; et al

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Abstract: Ciliated protists exhibit nuclear dimorphism through the presence of somatic macronuclei (MAC) and germline micronuclei (MIC). In some ciliates, DNA from precursor segments in the MIC genome rearranges to form transcriptionally active genes in the mature MAC genome, making these ciliates model organisms to study the process of somatic genome rearrangement. Similar broad scale, somatic rearrangement events occur in many eukaryotic cells and tumors. The <mds ies db> (http:// ies db) is a database of genome recombination and rearrangement annotations, and it provides tools for visualization and comparative analysis of precursor and product genomes. The database currently contains annotations for two completely sequenced ciliate genomes: Oxytricha trifallax and Tetrahymena thermophila.
Publication Date: 4-Jan-2016
Electronic Publication Date: 19-Nov-2015
Citation: Burns, Jonathan, Kukushkin, Denys, Lindblad, Kelsi, Chen, Xiao, Jonoska, Nataša, Landweber, Laura F. (2016). <mds_ies_db>: a database of ciliate genome rearrangements. Nucleic Acids Research, 44 (D1), D703 - D709. doi:10.1093/nar/gkv1190
DOI: doi:10.1093/nar/gkv1190
ISSN: 0305-1048
EISSN: 1362-4962
Pages: D703 - D709
Type of Material: Journal Article
Journal/Proceeding Title: Nucleic Acids Research
Version: Final published version. Article is made available in OAR by the publisher's permission or policy.

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