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Parallel Molecular Evolution in an Herbivore Community

Author(s): Zhen, Ying; Aardema, Matthew L.; Medina, Edgar M.; Schumer, Molly; Andolfatto, Peter

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Abstract: Numerous insects have independently evolved the ability to feed on plants that produce toxic secondary compounds called cardenolides and can sequester these compounds for use in their defense. We surveyed the protein target for cardenolides, the alpha subunit of the sodium pump, Na+,K+-ATPase (ATPα), in 14 species that feed on cardenolide-producing plants and 15 outgroups spanning three insect orders. Despite the large number of potential targets for modulating cardenolide sensitivity, amino acid substitutions associated with host-plant specialization are highly clustered, with many parallel substitutions. Additionally, we document four independent duplications of ATPα with convergent tissue-specific expression patterns. We find that unique substitutions are disproportionately associated with recent duplications relative to parallel substitutions. Together, these findings support the hypothesis that adaptation tends to take evolutionary paths that minimize negative pleiotropy.
Publication Date: 28-Sep-2012
Electronic Publication Date: 27-Sep-2012
Citation: Zhen, Y., Aardema, M.L., Medina, E.M., Schumer, M., Andolfatto, P. (2012). Parallel Molecular Evolution in an Herbivore Community. Science, 337 (6102), 1634 - 1637. doi:10.1126/science.1226630
DOI: doi:10.1126/science.1226630
ISSN: 0036-8075
EISSN: 1095-9203
Pages: 1634 - 1637
Type of Material: Journal Article
Journal/Proceeding Title: Science
Version: Author's manuscript

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