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Nuclear bodies: the emerging biophysics of nucleoplasmic phases

Author(s): Zhu, Lian; Brangwynne, Clifford P

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Abstract: The cell nucleus contains a large number of membrane-less bodies that play important roles in the spatiotemporal regulation of gene expression. Recent work suggests that low complexity/ disordered protein motifs and repetitive binding domains drive assembly of droplets of nuclear RNA/protein by promoting nucleoplasmic phase separation. Nucleation and maturation of these structures is regulated by, and may in turn affect, factors including post-translational modifications, protein concentration, transcriptional activity, and chromatin state. Here we present a concise review of these exciting recent advances, and discuss current and future challenges in understanding the assembly, regulation, and function of nuclear RNA/protein bodies.
Electronic Publication Date: 15-May-2015
Citation: Zhu, Lian, Brangwynne, Clifford P. (2015). Nuclear bodies: the emerging biophysics of nucleoplasmic phases. Current Opinion in Cell Biology, 34 (23 - 30. doi:10.1016/
DOI: doi:10.1016/
ISSN: 0955-0674
Pages: 23 - 30
Type of Material: Journal Article
Journal/Proceeding Title: Current Opinion in Cell Biology
Version: Author's manuscript
Notes: Electronic publication date given is for the publisher's version found on Elsevier's webpage, and not the author's manuscript.

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