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Nuclear bodies: the emerging biophysics of nucleoplasmic phases

Author(s): Zhu, Lian; Brangwynne, Clifford P

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dc.contributor.authorZhu, Lian-
dc.contributor.authorBrangwynne, Clifford P-
dc.identifier.citationZhu, Lian, Brangwynne, Clifford P. (2015). Nuclear bodies: the emerging biophysics of nucleoplasmic phases. Current Opinion in Cell Biology, 34 (23 - 30. doi:10.1016/
dc.descriptionElectronic publication date given is for the publisher's version found on Elsevier's webpage, and not the author's manuscript.en_US
dc.description.abstractThe cell nucleus contains a large number of membrane-less bodies that play important roles in the spatiotemporal regulation of gene expression. Recent work suggests that low complexity/ disordered protein motifs and repetitive binding domains drive assembly of droplets of nuclear RNA/protein by promoting nucleoplasmic phase separation. Nucleation and maturation of these structures is regulated by, and may in turn affect, factors including post-translational modifications, protein concentration, transcriptional activity, and chromatin state. Here we present a concise review of these exciting recent advances, and discuss current and future challenges in understanding the assembly, regulation, and function of nuclear RNA/protein bodies.en_US
dc.format.extent23 - 30en_US
dc.relation.ispartofCurrent Opinion in Cell Biologyen_US
dc.rightsAuthor's manuscripten_US
dc.titleNuclear bodies: the emerging biophysics of nucleoplasmic phasesen_US
dc.typeJournal Articleen_US

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