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An epigenetic aging clock for dogs and wolves

Author(s): Thompson, Michael J.; vonHoldt, Bridgett M.; Horvath, Steve; Pellegrini, Matteo

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Abstract: Several articles describe highly accurate age estimation methods based on human DNA‐methylation data. It is not yet known whether similar epigenetic aging clocks can be developed based on blood methylation data from canids. Using Reduced Representation Bisulfite Sequencing, we assessed blood DNA‐methylation data from 46 domesticated dogs (Canis familiaris) and 62 wild gray wolves (C. lupus). By regressing chronological dog age on the resulting CpGs, we defined highly accurate multivariate age estimators for dogs (based on 41 CpGs), wolves (67 CpGs), and both combined (115 CpGs). Age related DNA methylation changes in canids implicate similar gene ontology categories as those observed in humans suggesting an evolutionarily conserved mechanism underlying age‐related DNA methylation in mammals.
Electronic Publication Date: 28-Mar-2017
Citation: Thompson, Michael J., vonHoldt, Bridgett, Horvath, Steve, Pellegrini, Matteo. An epigenetic aging clock for dogs and wolves. Aging, 9(3), 1055 - 1068. doi: 10.18632/aging.101211
DOI: doi:10.18632/aging.101211
EISSN: 1945-4589
Pages: 1055 - 1068
Type of Material: Journal Article
Journal/Proceeding Title: Aging
Version: Final published version. This is an open access article.

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