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Combinatorial DNA rearrangement facilitates the origin of new genes in ciliates

Author(s): Chen, Xiao; Jung, Seolkyoung; Beh, Leslie Y; Eddy, Sean R; Landweber, Laura F

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dc.contributor.authorChen, Xiao-
dc.contributor.authorJung, Seolkyoung-
dc.contributor.authorBeh, Leslie Y-
dc.contributor.authorEddy, Sean R-
dc.contributor.authorLandweber, Laura F-
dc.date.accessioned2022-01-25T14:57:46Z-
dc.date.available2022-01-25T14:57:46Z-
dc.identifier.citationChen, Xiao, Jung, Seolkyoung, Beh, Leslie Y, Eddy, Sean R, Landweber, Laura F. (Combinatorial DNA rearrangement facilitates the origin of new genes in ciliates. Genome Biology and Evolution, evv172 - evv172. doi:10.1093/gbe/evv172en_US
dc.identifier.urihttp://arks.princeton.edu/ark:/88435/pr1nz80p80-
dc.description.abstractProgrammed genome rearrangements in the unicellular eukaryote Oxytricha trifallax produce a transcriptionally active somatic nucleus from a copy of its germline nucleus during development. This process eliminates noncoding sequences that interrupt coding regions in the germline genome, and joins over 225,000 remaining DNA segments, some of which require inversion or complex permutation to build functional genes. This dynamic genomic organization permits some single DNA segments in the germlineto contributeto multiple,distinctsomaticgenesvia alternativeprocessing.Like alternativemRNA splicing,the combinatorial assembly of DNA segments contributes to genetic variation and facilitates the evolution of new genes. In this study, we use comparative genomic analysis to demonstrate that the emergence of alternative DNA splicing is associated with the origin of new genes. Short duplications give rise to alternative gene segments that are spliced to the shared gene segments. Alternative gene segments evolve faster than shared, constitutive segments. Genes with shared segments frequently have different expression profiles, permitting functional divergence. This study reports alternative DNA splicing as a mechanism of new gene origination, illustrating how the process of programmed genome rearrangement gives rise to evolutionary innovation.en_US
dc.format.extent2859-2870en_US
dc.language.isoen_USen_US
dc.relation.ispartofGenome Biology and Evolutionen_US
dc.rightsFinal published version. Article is made available in OAR by the publisher's permission or policy.en_US
dc.titleCombinatorial DNA rearrangement facilitates the origin of new genes in ciliatesen_US
dc.typeJournal Articleen_US
dc.identifier.doidoi:10.1093/gbe/evv172-
dc.date.eissued2015-09-02en_US
dc.identifier.eissn1759-6653-
pu.type.symplectichttp://www.symplectic.co.uk/publications/atom-terms/1.0/journal-articleen_US

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