Skip to main content

A Quantitative Proteome Map of the Human Body.

Author(s): Jiang, Lihua; Wang, Meng; Lin, Shin; Jian, Ruiqi; Li, Xiao; et al

To refer to this page use:
Full metadata record
DC FieldValueLanguage
dc.contributor.authorJiang, Lihua-
dc.contributor.authorWang, Meng-
dc.contributor.authorLin, Shin-
dc.contributor.authorJian, Ruiqi-
dc.contributor.authorLi, Xiao-
dc.contributor.authorChan, Joanne-
dc.contributor.authorDong, Guanlan-
dc.contributor.authorFang, Huaying-
dc.contributor.authorRobinson, Aaron E-
dc.contributor.authorGTEx Consortium-
dc.contributor.authorSnyder, Michael P-
dc.identifier.citationJiang, Lihua, Meng Wang, Shin Lin, Ruiqi Jian, Xiao Li, Joanne Chan, Guanlan Dong, Huaying Fang, Aaron E. Robinson, GTEx Consortium, and Michael P. Snyder. "A quantitative proteome map of the human body." Cell 183, no. 1 (2020): 269-283.e19. doi:10.1016/j.cell.2020.08.036en_US
dc.description.abstractDetermining protein levels in each tissue and how they compare with RNA levels is important for understanding human biology and disease as well as regulatory processes that control protein levels. We quantified the relative protein levels from over 12,000 genes across 32 normal human tissues. Tissue-specific or tissue-enriched proteins were identified and compared to transcriptome data. Many ubiquitous transcripts are found to encode tissue-specific proteins. Discordance of RNA and protein enrichment revealed potential sites of synthesis and action of secreted proteins. The tissue-specific distribution of proteins also provides an in-depth view of complex biological events that require the interplay of multiple tissues. Most importantly, our study demonstrated that protein tissue-enrichment information can explain phenotypes of genetic diseases, which cannot be obtained by transcript information alone. Overall, our results demonstrate how understanding protein levels can provide insights into regulation, secretome, metabolism, and human diseases.en_US
dc.format.extent269 - 283.e19en_US
dc.rightsAuthor's manuscripten_US
dc.titleA Quantitative Proteome Map of the Human Body.en_US
dc.typeJournal Articleen_US

Files in This Item:
File Description SizeFormat 
QuantitativeMapBody.pdf2.37 MBAdobe PDFView/Download

Items in OAR@Princeton are protected by copyright, with all rights reserved, unless otherwise indicated.