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|Abstract:||This article demonstrates the first examples of tandem C–C and C–F bond formation for the palladium-catalyzed carbofluorination of allenes. The intramolecular Heck-fluorination cascade provides monofluoromethylated heteroarenes, an important class of products in medicinal chemistry. We also describe an intermolecular variant for the three-component coupling of allenes, aryl iodides, and AgF. Mechanistic studies indicate that C–F bond formation occurs by outer sphere attack of fluoride on an allylpalladium fluoride intermediate.|
|Citation:||Braun, Marie-Gabrielle, Katcher, Matthew H., Doyle, Abigail G. (2013). Carbofluorination via a palladium-catalyzed cascade reaction. Chemical Science, 4 (3), 1216 - 1216. doi:10.1039/c2sc22198e|
|Pages:||4, 1216 - 1216|
|Type of Material:||Journal Article|
|Journal/Proceeding Title:||Chemical Science|
|Version:||Final published version. Article is made available in OAR by the publisher's permission or policy.|
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