Carbofluorination via a palladium-catalyzed cascade reaction
Author(s): Braun, Marie-Gabrielle; Katcher, Matthew H.; Doyle, Abigail G.
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Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Braun, Marie-Gabrielle | - |
dc.contributor.author | Katcher, Matthew H. | - |
dc.contributor.author | Doyle, Abigail G. | - |
dc.date.accessioned | 2020-10-30T19:04:13Z | - |
dc.date.available | 2020-10-30T19:04:13Z | - |
dc.date.issued | 2013-01-04 | en_US |
dc.identifier.citation | Braun, Marie-Gabrielle, Katcher, Matthew H., Doyle, Abigail G. (2013). Carbofluorination via a palladium-catalyzed cascade reaction. Chemical Science, 4 (3), 1216 - 1216. doi:10.1039/c2sc22198e | en_US |
dc.identifier.issn | 2041-6520 | - |
dc.identifier.uri | http://arks.princeton.edu/ark:/88435/pr1mb9f | - |
dc.description.abstract | This article demonstrates the first examples of tandem C–C and C–F bond formation for the palladium-catalyzed carbofluorination of allenes. The intramolecular Heck-fluorination cascade provides monofluoromethylated heteroarenes, an important class of products in medicinal chemistry. We also describe an intermolecular variant for the three-component coupling of allenes, aryl iodides, and AgF. Mechanistic studies indicate that C–F bond formation occurs by outer sphere attack of fluoride on an allylpalladium fluoride intermediate. | en_US |
dc.format.extent | 4, 1216 - 1216 | en_US |
dc.language.iso | en | en_US |
dc.relation.ispartof | Chemical Science | en_US |
dc.rights | Final published version. Article is made available in OAR by the publisher's permission or policy. | en_US |
dc.title | Carbofluorination via a palladium-catalyzed cascade reaction | en_US |
dc.type | Journal Article | en_US |
dc.identifier.doi | doi:10.1039/c2sc22198e | - |
dc.identifier.eissn | 2041-6539 | - |
pu.type.symplectic | http://www.symplectic.co.uk/publications/atom-terms/1.0/journal-article | en_US |
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