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Carbofluorination via a palladium-catalyzed cascade reaction

Author(s): Braun, Marie-Gabrielle; Katcher, Matthew H.; Doyle, Abigail G.

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dc.contributor.authorBraun, Marie-Gabrielle-
dc.contributor.authorKatcher, Matthew H.-
dc.contributor.authorDoyle, Abigail G.-
dc.date.accessioned2020-10-30T19:04:13Z-
dc.date.available2020-10-30T19:04:13Z-
dc.date.issued2013-01-04en_US
dc.identifier.citationBraun, Marie-Gabrielle, Katcher, Matthew H., Doyle, Abigail G. (2013). Carbofluorination via a palladium-catalyzed cascade reaction. Chemical Science, 4 (3), 1216 - 1216. doi:10.1039/c2sc22198een_US
dc.identifier.issn2041-6520-
dc.identifier.urihttp://arks.princeton.edu/ark:/88435/pr1mb9f-
dc.description.abstractThis article demonstrates the first examples of tandem C–C and C–F bond formation for the palladium-catalyzed carbofluorination of allenes. The intramolecular Heck-fluorination cascade provides monofluoromethylated heteroarenes, an important class of products in medicinal chemistry. We also describe an intermolecular variant for the three-component coupling of allenes, aryl iodides, and AgF. Mechanistic studies indicate that C–F bond formation occurs by outer sphere attack of fluoride on an allylpalladium fluoride intermediate.en_US
dc.format.extent4, 1216 - 1216en_US
dc.language.isoenen_US
dc.relation.ispartofChemical Scienceen_US
dc.rightsFinal published version. Article is made available in OAR by the publisher's permission or policy.en_US
dc.titleCarbofluorination via a palladium-catalyzed cascade reactionen_US
dc.typeJournal Articleen_US
dc.identifier.doidoi:10.1039/c2sc22198e-
dc.identifier.eissn2041-6539-
pu.type.symplectichttp://www.symplectic.co.uk/publications/atom-terms/1.0/journal-articleen_US

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