Skip to main content

Dynamics of a morbillivirus at the domestic–wildlife interface: Canine distemper virus in domestic dogs and lions

Author(s): Viana, Mafalda; Cleaveland, Sarah; Matthiopoulos, Jason; Halliday, Jo; Packer, Craig; et al

To refer to this page use:
Abstract: Morbilliviruses cause many diseases of medical and veterinary importance, and although some (e.g., measles and rinderpest) have been controlled successfully, others, such as canine distemper virus (CDV), are a growing concern. A propensity for host-switching has resulted in CDV emergence in new species, including endangered wildlife, posing challenges for controlling disease in multispecies communities. CDV is typically associated with domestic dogs, but little is known about its maintenance and transmission in species-rich areas or about the potential role of domestic dog vaccination as a means of reducing disease threats to wildlife. We address these questions by analyzing a long-term serological dataset of CDV in lions and domestic dogs from Tanzania’s Serengeti ecosystem. Using a Bayesian state–space model, we show that dynamics of CDV have changed considerably over the past three decades. Initially, peaks of CDV infection in dogs preceded those in lions, suggesting that spill-over from dogs was the main driver of infection in wildlife. However, despite dog-to-lion transmission dominating cross-species transmission models, infection peaks in lions became more frequent and asynchronous from those in dogs, suggesting that other wildlife species may play a role in a potentially complex maintenance community. Widespread mass vaccination of domestic dogs reduced the probability of infection in dogs and the size of outbreaks but did not prevent transmission to or peaks of infection in lions. This study demonstrates the complexity of CDV dynamics in natural ecosystems and the value of long-term, large-scale datasets for investigating transmission patterns and evaluating disease control strategies.
Publication Date: 3-Feb-2015
Electronic Publication Date: 20-Jan-2015
Citation: Viana, Mafalda, Cleaveland, Sarah, Matthiopoulos, Jason, Halliday, Jo, Packer, Craig, Craft, Meggan E, Hampson, Katie, Czupryna, Anna, Dobson, Andrew P, Dubovi, Edward J, Ernest, Eblate, Fyumagwa, Robert, Hoare, Richard, Hopcraft, J Grant C, Horton, Daniel L, Kaare, Magai T, Kanellos, Theo, Lankester, Felix, Mentzel, Christine, Mlengeya, Titus, Mzimbiri, Imam, Takahashi, Emi, Willett, Brian, Haydon, Daniel T, Lembo, Tiziana. (2015). Dynamics of a morbillivirus at the domestic–wildlife interface: Canine distemper virus in domestic dogs and lions. Proceedings of the National Academy of Sciences, 112 (5), 1464 - 1469. doi:10.1073/pnas.1411623112
DOI: doi:10.1073/pnas.1411623112
ISSN: 0027-8424
EISSN: 1091-6490
Pages: 1464 - 1469
Type of Material: Journal Article
Journal/Proceeding Title: Proceedings of the National Academy of Sciences
Version: Final published version. This is an open access article.

Items in OAR@Princeton are protected by copyright, with all rights reserved, unless otherwise indicated.