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Lymphocyte invasion in IC10/basal-like breast tumors is associated with wild-type TP53

Author(s): Quigley, D; Silwal-Pandit, L; Dannenfelser, R; Langerød, A; Vollan, HKM; et al

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Abstract: Lymphocytic infiltration is associated with better prognosis in several epithelial malignancies including breast cancer. The tumor suppressor TP53 is mutated in approximately 30% of breast adenocarcinomas, with varying frequency across molecular subtypes. In this study of 1,420 breast tumors, we tested for interaction between TP53 mutation status and tumor subtype determined by PAM50 and integrative cluster analysis. In integrative cluster 10 (IC10)/basal-like breast cancer, we identify an association between lymphocytic infiltration, determined by an expression score, and retention of wild-type TP53. The expressionderived score agreed with the degree of lymphocytic infiltration assessed by pathologic review, and application of the Nanodissect algorithm was suggestive of this infiltration being primarily of cytotoxic T lymphocytes (CTL). Elevated expression of this CTL signature was associated with longer survival in IC10/Basal-like tumors. These findings identify a new link between the TP53 pathway and the adaptive immune response in estrogen receptor (ER)-negative breast tumors, suggesting a connection between TP53 inactivation and failure of tumor immunosurveillance.
Publication Date: 28-Oct-2015
Electronic Publication Date: 28-Oct-2015
Citation: Quigley, D, Silwal-Pandit, L, Dannenfelser, R, Langerød, A, Vollan, HKM, Vaske, C, Siegel, JU, Troyanskaya, O, Chin, S-F, Caldas, C, Balmain, A, Børresen-Dale, A-L, Kristensen, V. (2015). Lymphocyte invasion in IC10/basal-like breast tumors is associated with wild-type TP53. Molecular Cancer Research, 13 (493 - 501. doi:10.1158/1541-7786.MCR-14-0387
DOI: doi:10.1158/1541-7786.MCR-14-0387
Pages: 493 - 501
Type of Material: Journal Article
Journal/Proceeding Title: Molecular Cancer Research
Version: Author's manuscript

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