Skip to main content

Growth factor gene IGF1 is associated with bill size in the black-bellied seedcracker Pyrenestes ostrinus.

Author(s): vonHoldt, Bridgett M.; Kartzinel, Rebecca Y.; Huber, Christian D.; Le Underwood, Vinh; Zhen, Ying; et al

Download
To refer to this page use: http://arks.princeton.edu/ark:/88435/pr1jt6t
Full metadata record
DC FieldValueLanguage
dc.contributor.authorvonHoldt, Bridgett M.-
dc.contributor.authorKartzinel, Rebecca Y.-
dc.contributor.authorHuber, Christian D.-
dc.contributor.authorLe Underwood, Vinh-
dc.contributor.authorZhen, Ying-
dc.contributor.authorRuegg, Kristen-
dc.contributor.authorLohmueller, Kirk E.-
dc.contributor.authorSmith, Thomas B.-
dc.date.accessioned2019-04-19T18:37:45Z-
dc.date.available2019-04-19T18:37:45Z-
dc.date.issued2018-11-19en_US
dc.identifier.citationvonHoldt, Bridgett M., Kartzinel, Rebecca Y., Huber, Christian D., Le Underwood, Vinh, Zhen, Ying, Ruegg, Kristen, Lohmueller, Kirk E., Smith, Thomas B. (2018). Growth factor gene IGF1 is associated with bill size in the black-bellied seedcracker Pyrenestes ostrinus. Nature communications, 9 (1), 4855 - 4855. doi:10.1038/s41467-018-07374-9en_US
dc.identifier.issn2041-1723-
dc.identifier.urihttp://arks.princeton.edu/ark:/88435/pr1jt6t-
dc.description.abstractPyrenestes finches are unique among birds in showing a non-sex-determined polymorphism in bill size and are considered a textbook example of disruptive selection. Morphs breed randomly with respect to bill size, and differ in diet and feeding performance relative to seed hardness. Previous breeding experiments are consistent with the polymorphism being controlled by a single genetic factor. Here, we use genome-wide pooled sequencing to explore the underlying genetic basis of bill morphology and identify a single candidate region. Targeted resequencing reveals extensive linkage disequilibrium across a 300 Kb region containing the insulin-like growth factor 1 (IGF1) gene, with a single 5-million-year-old haplotype associating with phenotypic dominance of the large-billed morph. We find no genetic similarities controlling bill size in the well-studied Darwin's finches (Geospiza). Our results show how a single genetic factor may control bill size and provide a foundation for future studies to examine this phenomenon within and among avian species.en_US
dc.format.extent4855 - 4855en_US
dc.languageengen_US
dc.language.isoen_USen_US
dc.relation.ispartofNature communicationsen_US
dc.rightsFinal published version. This is an open access article.en_US
dc.titleGrowth factor gene IGF1 is associated with bill size in the black-bellied seedcracker Pyrenestes ostrinus.en_US
dc.typeJournal Articleen_US
dc.identifier.doidoi:10.1038/s41467-018-07374-9-
dc.identifier.eissn2041-1723-
pu.type.symplectichttp://www.symplectic.co.uk/publications/atom-terms/1.0/journal-articleen_US

Files in This Item:
File Description SizeFormat 
Growth_factor_gene_IGF1_2018.pdf2.06 MBAdobe PDFView/Download


Items in OAR@Princeton are protected by copyright, with all rights reserved, unless otherwise indicated.