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The Drosophila melanogaster Genetic Reference Panel

Author(s): Mackay, Trudy F. C.; Richards, Stephen; Stone, Eric A.; Barbadilla, Antonio; Ayroles, Julien F.; et al

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dc.contributor.authorMackay, Trudy F. C.-
dc.contributor.authorRichards, Stephen-
dc.contributor.authorStone, Eric A.-
dc.contributor.authorBarbadilla, Antonio-
dc.contributor.authorAyroles, Julien F.-
dc.contributor.authorZhu, Dianhui-
dc.contributor.authorCasillas, Sònia-
dc.contributor.authorHan, Yi-
dc.contributor.authorMagwire, Michael M-
dc.contributor.authorCridland, Julie M.-
dc.contributor.authorRichardson, Mark F.-
dc.contributor.authorAnholt, Robert R.H.-
dc.contributor.authorBarrón, Maite-
dc.contributor.authorBess, Crystal-
dc.contributor.authorBlankenburg, Kerstin Petra-
dc.contributor.authorCarbone, Mary Anna-
dc.contributor.authorCastellano, David-
dc.contributor.authorChaboub, Lesley-
dc.contributor.authorDuncan, Laura-
dc.contributor.authorHarris, Zeke-
dc.contributor.authorJavaid, Mehwish-
dc.contributor.authorJayaseelan, Joy Christina-
dc.contributor.authorJhangiani, Shalini N.-
dc.contributor.authorJordan, Katherine W.-
dc.contributor.authorLara, Fremiet-
dc.contributor.authorLawrence, Faye-
dc.contributor.authorLee, Sandra L.-
dc.contributor.authorLibrado, Pablo-
dc.contributor.authorLinheiro, Raquel S.-
dc.contributor.authorLyman, Richard F.-
dc.contributor.authorMackey, Aaron J.-
dc.contributor.authorMunidasa, Mala-
dc.contributor.authorMuzny, Donna Marie-
dc.contributor.authorNazareth, Lynne-
dc.contributor.authorNewsham, Irene-
dc.contributor.authorPerales, Lora-
dc.contributor.authorPu, Ling-Ling-
dc.contributor.authorQu, Carson-
dc.contributor.authorRàmia, Miquel-
dc.contributor.authorReid, Jeffrey G.-
dc.contributor.authorRollmann, Stephanie M.-
dc.contributor.authorRozas, Julio-
dc.contributor.authorSaada, Nehad-
dc.contributor.authorTurlapati, Lavanya-
dc.contributor.authorWorley, Kim C.-
dc.contributor.authorWu, Yuan-Qing-
dc.contributor.authorYamamoto, Akihiko-
dc.contributor.authorZhu, Yiming-
dc.contributor.authorBergman, Casey M.-
dc.contributor.authorThornton, Kevin R.-
dc.contributor.authorMittelman, David-
dc.contributor.authorGibbs, Richard A.-
dc.date.accessioned2019-04-19T18:34:12Z-
dc.date.available2019-04-19T18:34:12Z-
dc.date.issued2012-02-08en_US
dc.identifier.citationMackay, Trudy FC, Richards, Stephen, Stone, Eric A, Barbadilla, Antonio, Ayroles, Julien F, Zhu, Dianhui, Casillas, Sònia, Han, Yi, Magwire, Michael M, Cridland, Julie M, Richardson, Mark F, Anholt, Robert RH, Barrón, Maite, Bess, Crystal, Blankenburg, Kerstin Petra, Carbone, Mary Anna, Castellano, David, Chaboub, Lesley, Duncan, Laura, Harris, Zeke, Javaid, Mehwish, Jayaseelan, Joy Christina, Jhangiani, Shalini N, Jordan, Katherine W, Lara, Fremiet, Lawrence, Faye, Lee, Sandra L, Librado, Pablo, Linheiro, Raquel S, Lyman, Richard F, Mackey, Aaron J, Munidasa, Mala, Muzny, Donna Marie, Nazareth, Lynne, Newsham, Irene, Perales, Lora, Pu, Ling-Ling, Qu, Carson, Ràmia, Miquel, Reid, Jeffrey G, Rollmann, Stephanie M, Rozas, Julio, Saada, Nehad, Turlapati, Lavanya, Worley, Kim C, Wu, Yuan-Qing, Yamamoto, Akihiko, Zhu, Yiming, Bergman, Casey M, Thornton, Kevin R, Mittelman, David, Gibbs, Richard A. (2012). The Drosophila melanogaster Genetic Reference Panel. Nature, 482 (7384), 173 - 178. doi:10.1038/nature10811en_US
dc.identifier.issn0028-0836-
dc.identifier.urihttp://arks.princeton.edu/ark:/88435/pr1jq4v-
dc.description.abstractA major challenge of biology is understanding the relationship between molecular genetic variation and variation in quantitative traits, including fitness. This relationship determines our ability to predict phenotypes from genotypes and to understand how evolutionary forces shape variation within and between species. Previous efforts to dissect the genotype–phenotype map were based on incomplete genotypic information. Here, we describe the Drosophila melanogaster Genetic Reference Panel (DGRP), a community resource for analysis of population genomics and quantitative traits. The DGRP consists of fully sequenced inbred lines derived from a natural population. Population genomic analyses reveal reduced polymorphism in centromeric autosomal regions and the X chromosome, evidence for positive and negative selection, and rapid evolution of the X chromosome. Many variants in novel genes, most at low frequency, are associated with quantitative traits and explain a large fraction of the phenotypic variance. The DGRP facilitates genotype–phenotype mapping using the power of Drosophila genetics.en_US
dc.format.extent173 - 178en_US
dc.language.isoen_USen_US
dc.relation.ispartofNatureen_US
dc.rightsFinal published version. This is an open access article.en_US
dc.titleThe Drosophila melanogaster Genetic Reference Panelen_US
dc.typeJournal Articleen_US
dc.identifier.doidoi:10.1038/nature10811-
dc.date.eissued2012-02-08en_US
dc.identifier.eissn1476-4687-
pu.type.symplectichttp://www.symplectic.co.uk/publications/atom-terms/1.0/journal-articleen_US

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