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Integrative pathway enrichment analysis of multivariate omics data

Author(s): Paczkowska, Marta; Barenboim, Jonathan; Sintupisut, Nardnisa; Fox, Natalie S; Zhu, Helen; et al

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dc.contributor.authorPaczkowska, Marta-
dc.contributor.authorBarenboim, Jonathan-
dc.contributor.authorSintupisut, Nardnisa-
dc.contributor.authorFox, Natalie S-
dc.contributor.authorZhu, Helen-
dc.contributor.authorAbd-Rabbo, Diala-
dc.contributor.authorMee, Miles W-
dc.contributor.authorBoutros, Paul C-
dc.contributor.authorPCAWG Drivers and Functional Interpretation Working Group-
dc.contributor.authorReimand, Jüri-
dc.contributor.authorPCAWG Consortium-
dc.identifier.citationPaczkowska, Marta, Jonathan Barenboim, Nardnisa Sintupisut, Natalie S. Fox, Helen Zhu, Diala Abd-Rabbo, Miles W. Mee, Paul C. Boutros, PCAWG Drivers and Functional Interpretation Working Group, Jüri Reimand, and PCAWG Consortium. "Integrative pathway enrichment analysis of multivariate omics data." Nature Communications 11, no. 1 (2020). doi:10.1038/s41467-019-13983-9en_US
dc.descriptionSupplementary Information:
dc.description.abstractMulti-omics datasets represent distinct aspects of the central dogma of molecular biology. Such high-dimensional molecular profiles pose challenges to data interpretation and hypothesis generation. ActivePathways is an integrative method that discovers significantly enriched pathways across multiple datasets using statistical data fusion, rationalizes contributing evidence and highlights associated genes. As part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, which aggregated whole genome sequencing data from 2658 cancers across 38 tumor types, we integrated genes with coding and non-coding mutations and revealed frequently mutated pathways and additional cancer genes with infrequent mutations. We also analyzed prognostic molecular pathways by integrating genomic and transcriptomic features of 1780 breast cancers and highlighted associations with immune response and anti-apoptotic signaling. Integration of ChIP-seq and RNA-seq data for master regulators of the Hippo pathway across normal human tissues identified processes of tissue regeneration and stem cell regulation. ActivePathways is a versatile method that improves systems-level understanding of cellular organization in health and disease through integration of multiple molecular datasets and pathway annotations.en_US
dc.relation.ispartofNature Communicationsen_US
dc.rightsFinal published version. This is an open access article.en_US
dc.titleIntegrative pathway enrichment analysis of multivariate omics dataen_US
dc.typeJournal Articleen_US

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