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LUCApedia: a database for the study of ancient life

Author(s): Goldman, Aaron David; Bernhard, Tess M; Dolzhenko, Egor; Landweber, Laura F

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Abstract: Organisms represented by the root of the universal evolutionary tree were most likely complex cells with a sophisticated protein translation system and a DNA genome encoding hundreds of genes. The growth of bioinformatics data from taxonomically diverse organisms has made it possible to infer the likely properties of early life in greater detail. Here we present LUCApedia, (http://eeb.princeton. edu/lucapedia), a unified framework for simultaneously evaluating multiple data sets related to the Last Universal Common Ancestor (LUCA) and its predecessors. This unification is achieved by mapping eleven such data sets onto UniProt, KEGG and BioCyc IDs. LUCApedia may be used to rapidly acquire evidence that a certain gene or set of genes is ancient, to examine the early evolution of metabolic pathways, or to test specific hypotheses related to ancient life by corroborating them against the rest of the database.
Publication Date: 26-Nov-2012
Electronic Publication Date: 27-Nov-2012
Citation: Goldman, Aaron David, Bernhard, Tess M, Dolzhenko, Egor, Landweber, Laura F. (2012). LUCApedia: a database for the study of ancient life. Nucleic Acids Research, 41 (D1), D1079 - D1082. doi:10.1093/nar/gks1217
DOI: doi:10.1093/nar/gks1217
ISSN: 0305-1048
EISSN: 1362-4962
Pages: D1079 - D1082
Type of Material: Journal Article
Journal/Proceeding Title: Nucleic Acids Research
Version: Final published version. Article is made available in OAR by the publisher's permission or policy.

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