Nickel-catalyzed enantioselective arylation of pyridine
Author(s): Lutz, J. Patrick; Chau, Stephen T.; Doyle, Abigail G.
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Abstract: | We report an enantioselective Ni-catalyzed cross coupling of arylzinc reagents with pyridinium ions formed in situ from pyridine and a chloroformate. This reaction provides enantioenriched 2-aryl-1,2- dihydropyridine products that can be elaborated to numerous piperidine derivatives with little or no loss in ee. This method is notable for its use of pyridine, a feedstock chemical, to build a versatile, chiral heterocycle in a single synthetic step. |
Publication Date: | 8-Mar-2016 |
Electronic Publication Date: | 2016 |
Citation: | Lutz, J. Patrick, Chau, Stephen T., Doyle, Abigail G. (2016). Nickel-catalyzed enantioselective arylation of pyridine. Chemical Science, 7 (7), 4105 - 4109. doi:10.1039/C6SC00702C |
DOI: | doi:10.1039/C6SC00702C |
ISSN: | 2041-6520 |
EISSN: | 2041-6539 |
Pages: | 7, 4105 - 4109 |
Type of Material: | Journal Article |
Journal/Proceeding Title: | Chemical Science |
Version: | Final published version. Article is made available in OAR by the publisher's permission or policy. |
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