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Nickel-catalyzed enantioselective arylation of pyridine

Author(s): Lutz, J. Patrick; Chau, Stephen T.; Doyle, Abigail G.

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Abstract: We report an enantioselective Ni-catalyzed cross coupling of arylzinc reagents with pyridinium ions formed in situ from pyridine and a chloroformate. This reaction provides enantioenriched 2-aryl-1,2- dihydropyridine products that can be elaborated to numerous piperidine derivatives with little or no loss in ee. This method is notable for its use of pyridine, a feedstock chemical, to build a versatile, chiral heterocycle in a single synthetic step.
Publication Date: 8-Mar-2016
Electronic Publication Date: 2016
Citation: Lutz, J. Patrick, Chau, Stephen T., Doyle, Abigail G. (2016). Nickel-catalyzed enantioselective arylation of pyridine. Chemical Science, 7 (7), 4105 - 4109. doi:10.1039/C6SC00702C
DOI: doi:10.1039/C6SC00702C
ISSN: 2041-6520
EISSN: 2041-6539
Pages: 7, 4105 - 4109
Type of Material: Journal Article
Journal/Proceeding Title: Chemical Science
Version: Final published version. Article is made available in OAR by the publisher's permission or policy.

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