Nickel-catalyzed enantioselective arylation of pyridine

Lutz, J. Patrick; Chau, Stephen T.; Doyle, Abigail G.

Nickel-catalyzed enantioselective arylation of pyridine

Author(s): Lutz, J. Patrick; Chau, Stephen T.; Doyle, Abigail G.

Download

To refer to this page use: http://arks.princeton.edu/ark:/88435/pr1bv5q

Full metadata record

DC Field	Value	Language
dc.contributor.author	Lutz, J. Patrick	-
dc.contributor.author	Chau, Stephen T.	-
dc.contributor.author	Doyle, Abigail G.	-
dc.date.accessioned	2020-10-30T19:04:15Z	-
dc.date.available	2020-10-30T19:04:15Z	-
dc.date.issued	2016-03-08	en_US
dc.identifier.citation	Lutz, J. Patrick, Chau, Stephen T., Doyle, Abigail G. (2016). Nickel-catalyzed enantioselective arylation of pyridine. Chemical Science, 7 (7), 4105 - 4109. doi:10.1039/C6SC00702C	en_US
dc.identifier.issn	2041-6520	-
dc.identifier.uri	http://arks.princeton.edu/ark:/88435/pr1bv5q	-
dc.description.abstract	We report an enantioselective Ni-catalyzed cross coupling of arylzinc reagents with pyridinium ions formed in situ from pyridine and a chloroformate. This reaction provides enantioenriched 2-aryl-1,2- dihydropyridine products that can be elaborated to numerous piperidine derivatives with little or no loss in ee. This method is notable for its use of pyridine, a feedstock chemical, to build a versatile, chiral heterocycle in a single synthetic step.	en_US
dc.format.extent	7, 4105 - 4109	en_US
dc.language.iso	en	en_US
dc.relation.ispartof	Chemical Science	en_US
dc.rights	Final published version. Article is made available in OAR by the publisher's permission or policy.	en_US
dc.title	Nickel-catalyzed enantioselective arylation of pyridine	en_US
dc.type	Journal Article	en_US
dc.identifier.doi	doi:10.1039/C6SC00702C	-
dc.date.eissued	2016	en_US
dc.identifier.eissn	2041-6539	-
pu.type.symplectic	http://www.symplectic.co.uk/publications/atom-terms/1.0/journal-article	en_US

Files in This Item:

File	Description	Size	Format
c6sc00702c.pdf		714.16 kB	Adobe PDF	View/Download

Show Simple Item Record