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# Learning a neural response metric for retinal prosthesis

## Author(s): Shah, Nishal P; Madugula, Sasidhar; Chichilnisky, EJ; Singer, Yoram; Shlens, Jonathon

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 Abstract: Retinal prostheses for treating incurable blindness are designed to electrically stimulate surviving retinal neurons, causing them to send artificial visual signals to the brain. However, electrical stimulation generally cannot precisely reproduce typical patterns of neural activity in the retina. Therefore, an electrical stimulus must be selected so as to produce a neural response as close as possible to the desired response. This requires a technique for computing the distance between a desired response and an achievable response that is meaningful in terms of the visual signal being conveyed. We propose a method to learn a metric on neural responses directly from recorded light responses of a population of retinal ganglion cells (RGCs) in the primate retina. The learned metric produces a measure of similarity of RGC population responses that accurately reflects the similarity of visual inputs. Using data from electrical stimulation experiments, we demonstrate that the learned metric could produce improvements in the performance of a retinal prosthesis. Publication Date: 2018 Citation: Shah, Nishal P., Sasidhar Madugula, E. J. Chichilnisky, Yoram Singer, and Jonathon Shlens. "Learning a neural response metric for retinal prosthesis." In International Conference on Learning Representations (2018). Type of Material: Conference Article Journal/Proceeding Title: International Conference on Learning Representations Version: Author's manuscript

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