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Discovering the Phylodynamics of RNA Viruses

Author(s): Holmes, Edward C.; Grenfell, Bryan T.

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Abstract: The advent of extremely high throughput DNA sequencing ensures that genomic data from microbial organisms can be acquired in unprecedented quantities and with remarkable rapidity. Although this genomic revolution will affect all microbes alike, our focus here is on RNA viruses, as the rapidity of their evolution, which is observable over the time scale of human observation, allows phylodynamic inferences to be made with great precision. In the foreseeable future it is likely that complete genome sequencing will become the standard method of viral characterization, providing the highest possible resolution for phylogenetic studies. The rapidity with which genome sequence data were generated from the ongoing epidemic of swine-origin H1N1 influenza A virus [1] is testament to the power of this technology.
Publication Date: 26-Oct-2009
Electronic Publication Date: 26-Oct-2009
Citation: Holmes, Edward C., Grenfell, Bryan T. (2009). Discovering the Phylodynamics of RNA Viruses. PLoS Computational Biology, 5 (10), e1000505 - e1000505. doi:10.1371/journal.pcbi.1000505
DOI: doi:10.1371/journal.pcbi.1000505
EISSN: 1553-7358
Pages: e1000505 - e1000505
Type of Material: Journal Article
Journal/Proceeding Title: PLoS Computational Biology
Version: Final published version. This is an open access article.

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