Skip to main content

The Physarum polycephalum Genome Reveals Extensive Use of Prokaryotic Two-Component and Metazoan-Type Tyrosine Kinase Signaling

Author(s): Schaap, Pauline; Barrantes, Israel; Minx, Pat; Sasaki, Narie; Anderson, Roger W; et al

Download
To refer to this page use: http://arks.princeton.edu/ark:/88435/pr1513tv5g
Full metadata record
DC FieldValueLanguage
dc.contributor.authorSchaap, Pauline-
dc.contributor.authorBarrantes, Israel-
dc.contributor.authorMinx, Pat-
dc.contributor.authorSasaki, Narie-
dc.contributor.authorAnderson, Roger W-
dc.contributor.authorBénard, Marianne-
dc.contributor.authorBiggar, Kyle K-
dc.contributor.authorBuchler, Nicolas E-
dc.contributor.authorBundschuh, Ralf-
dc.contributor.authorChen, Xiao-
dc.contributor.authorFronick, Catrina-
dc.contributor.authorFulton, Lucinda-
dc.contributor.authorGolderer, Georg-
dc.contributor.authorJahn, Niels-
dc.contributor.authorKnoop, Volker-
dc.contributor.authorLandweber, Laura F-
dc.contributor.authorMaric, Chrystelle-
dc.contributor.authorMiller, Dennis-
dc.contributor.authorNoegel, Angelika A-
dc.contributor.authorPeace, Rob-
dc.contributor.authorPierron, Gérard-
dc.contributor.authorSasaki, Taeko-
dc.contributor.authorSchallenberg-Rüdinger, Mareike-
dc.contributor.authorSchleicher, Michael-
dc.contributor.authorSingh, Reema-
dc.contributor.authorSpaller, Thomas-
dc.contributor.authorStorey, Kenneth B-
dc.contributor.authorSuzuki, Takamasa-
dc.contributor.authorTomlinson, Chad-
dc.contributor.authorTyson, John J-
dc.contributor.authorWarren, Wesley C-
dc.contributor.authorWerner, Ernst R-
dc.contributor.authorWerner-Felmayer, Gabriele-
dc.contributor.authorWilson, Richard K-
dc.contributor.authorWinckler, Thomas-
dc.contributor.authorGott, Jonatha M-
dc.contributor.authorGlöckner, Gernot-
dc.contributor.authorMarwan, Wolfgang-
dc.date.accessioned2022-01-25T14:57:48Z-
dc.date.available2022-01-25T14:57:48Z-
dc.date.issued2016-01en_US
dc.identifier.citationSchaap, Pauline, Barrantes, Israel, Minx, Pat, Sasaki, Narie, Anderson, Roger W, Bénard, Marianne, Biggar, Kyle K, Buchler, Nicolas E, Bundschuh, Ralf, Chen, Xiao, Fronick, Catrina, Fulton, Lucinda, Golderer, Georg, Jahn, Niels, Knoop, Volker, Landweber, Laura F, Maric, Chrystelle, Miller, Dennis, Noegel, Angelika A, Peace, Rob, Pierron, Gérard, Sasaki, Taeko, Schallenberg-Rüdinger, Mareike, Schleicher, Michael, Singh, Reema, Spaller, Thomas, Storey, Kenneth B, Suzuki, Takamasa, Tomlinson, Chad, Tyson, John J, Warren, Wesley C, Werner, Ernst R, Werner-Felmayer, Gabriele, Wilson, Richard K, Winckler, Thomas, Gott, Jonatha M, Glöckner, Gernot, Marwan, Wolfgang. (2016). The Physarum polycephalum Genome Reveals Extensive Use of Prokaryotic Two-Component and Metazoan-Type Tyrosine Kinase Signaling. Genome Biology and Evolution, 8 (1), 109 - 125. doi:10.1093/gbe/evv237en_US
dc.identifier.urihttp://arks.princeton.edu/ark:/88435/pr1513tv5g-
dc.description.abstractPhysarum polycephalum is a well-studied microbial eukaryote with unique experimental attributes relative to other experimental model organisms. It has a sophisticated life cycle with several distinct stages including amoebal, flagellated, and plasmodial cells. It is unusual in switching between open and closed mitosis according to specific life-cycle stages. Here we present the analysis of the genome of this enigmatic and important model organism and compare it with closely related species. The genome is littered with simple and complex repeats and the coding regions are frequently interrupted by introns with a mean size of 100 bases. Complemented with extensive transcriptome data, we define approximately 31,000 gene loci, providing unexpected insights into early eukaryote evolution. We describe extensive use of histidine kinase-based two-component systems and tyrosine kinase signaling, the presence of bacterial and plant type photoreceptors (phytochromes, cryptochrome, and phototropin) and of plant-type pentatricopeptide repeat proteins, as well as metabolic pathways, and a cell cycle control system typically found in more complex eukaryotes. Our analysis characterizes P. polycephalum as a prototypical eukaryote with features attributed to the last common ancestor of Amorphea, that is, the Amoebozoa and Opisthokonts. Specifically, the presence of tyrosine kinases in Acanthamoeba and Physarum as representatives of two distantly related subdivisions of Amoebozoa argues against the later emergence of tyrosine kinase signaling in the opisthokont lineage and also against the acquisition by horizontal gene transfer.en_US
dc.format.extent109 - 125en_US
dc.language.isoen_USen_US
dc.relation.ispartofGenome Biology and Evolutionen_US
dc.rightsFinal published version. Article is made available in OAR by the publisher's permission or policy.en_US
dc.titleThe Physarum polycephalum Genome Reveals Extensive Use of Prokaryotic Two-Component and Metazoan-Type Tyrosine Kinase Signalingen_US
dc.typeJournal Articleen_US
dc.identifier.doidoi:10.1093/gbe/evv237-
dc.date.eissued2015-11-27en_US
dc.identifier.eissn1759-6653-
pu.type.symplectichttp://www.symplectic.co.uk/publications/atom-terms/1.0/journal-articleen_US

Files in This Item:
File Description SizeFormat 
the_physarum_genome_tyrosine_kinase_signaling.pdf1.15 MBAdobe PDFView/Download


Items in OAR@Princeton are protected by copyright, with all rights reserved, unless otherwise indicated.