Skip to main content

Site-selective 18F fluorination of unactivated C-H bonds mediated by a manganese porphyrin

Author(s): Hooker, Jacob M.; Liu, Wei; Huang, Xiongyi; Placzek, Michael S.; Krska, Shane W.; et al

To refer to this page use:
Abstract: © The Royal Society of Chemistry 2018. The first direct C-H 18F fluorination reaction of unactivated aliphatic sites using no-carrier-Added [18F]fluoride is reported. Under the influence of a manganese porphyrin/iodosylbenzene system, a variety of unactivated aliphatic C-H bonds can be selectively converted to C-18F bonds. The mild conditions, broad substrate scope and generally inaccessible regiochemistry make this radio-fluorination a powerful alternate to established nucleophilic substitution for the preparation of 18F labeled radio tracers.
Publication Date: 5-Dec-2017
Electronic Publication Date: 1-Jan-2018
Citation: Liu, W., Huang, X., Placzek, M.S., Krska, S.W, McQuade, P., Hooker, J.M., Groves, J.T. (2018). Site-selective <sup>18</sup>F fluorination of unactivated C-H bonds mediated by a manganese porphyrin. Chemical Science, 9 (5), 1168 - 1172. doi:10.1039/c7sc04545j
DOI: doi:10.1039/c7sc04545j
ISSN: 2041-6520
EISSN: 2041-6539
Pages: 9.5:1168 - 1172
Type of Material: Journal Article
Journal/Proceeding Title: Chemical Science
Version: Final published version. This is an open access article.
Notes: Chemical Science. Volume 9, Issue 5, 2018, Pages 1168-1172. First published on 5th December 2017

Items in OAR@Princeton are protected by copyright, with all rights reserved, unless otherwise indicated.