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Site-selective 18F fluorination of unactivated C-H bonds mediated by a manganese porphyrin

Author(s): Hooker, Jacob M.; Liu, Wei; Huang, Xiongyi; Placzek, Michael S.; Krska, Shane W.; et al

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dc.contributor.authorHooker, Jacob M.-
dc.contributor.authorLiu, Wei-
dc.contributor.authorHuang, Xiongyi-
dc.contributor.authorPlaczek, Michael S.-
dc.contributor.authorKrska, Shane W.-
dc.contributor.authorMcQuade, Paul-
dc.contributor.authorGroves, John T.-
dc.contributor.authorLiu, Wei-
dc.contributor.authorLiu, Wei-
dc.contributor.authorLiu, Wei-
dc.contributor.authorLiu, Wei-
dc.contributor.authorLiu, Wei-
dc.contributor.authorLiu, Wei-
dc.date.accessioned2020-11-12T18:51:27Z-
dc.date.available2020-11-12T18:51:27Z-
dc.date.issued2017-12-05en_US
dc.identifier.citationLiu, W., Huang, X., Placzek, M.S., Krska, S.W, McQuade, P., Hooker, J.M., Groves, J.T. (2018). Site-selective <sup>18</sup>F fluorination of unactivated C-H bonds mediated by a manganese porphyrin. Chemical Science, 9 (5), 1168 - 1172. doi:10.1039/c7sc04545jen_US
dc.identifier.issn2041-6520-
dc.identifier.urihttp://arks.princeton.edu/ark:/88435/pr14n76-
dc.descriptionChemical Science. Volume 9, Issue 5, 2018, Pages 1168-1172. First published on 5th December 2017en_US
dc.description.abstract© The Royal Society of Chemistry 2018. The first direct C-H 18F fluorination reaction of unactivated aliphatic sites using no-carrier-Added [18F]fluoride is reported. Under the influence of a manganese porphyrin/iodosylbenzene system, a variety of unactivated aliphatic C-H bonds can be selectively converted to C-18F bonds. The mild conditions, broad substrate scope and generally inaccessible regiochemistry make this radio-fluorination a powerful alternate to established nucleophilic substitution for the preparation of 18F labeled radio tracers.en_US
dc.format.extent9.5:1168 - 1172en_US
dc.language.isoenen_US
dc.relation.ispartofChemical Scienceen_US
dc.rightsFinal published version. This is an open access article.en_US
dc.titleSite-selective 18F fluorination of unactivated C-H bonds mediated by a manganese porphyrinen_US
dc.typeJournal Articleen_US
dc.identifier.doidoi:10.1039/c7sc04545j-
dc.date.eissued2018-01-01en_US
dc.identifier.eissn2041-6539-
pu.type.symplectichttp://www.symplectic.co.uk/publications/atom-terms/1.0/journal-articleen_US

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