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Does Exposure to Stressors Predict Changes in Physiological Dysregulation?

Author(s): Glei, Dana A; Goldman, Noreen; Wu, Chih-Hsun; Weinstein, Maxine

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Abstract: Background— The allostatic load framework implies that cumulative exposure to stressors results in multi-system physiological dysregulation. Purpose— To investigate the effect of stress burden on subsequent changes (2000-2006) in physiological dysregulation. Methods— Data came from a population-based cohort study in Taiwan (n=521, aged 54+ in 2000, re-examined in 2006). Measures of stressful events and chronic strain were based on questions asked in 1996, 1999, and 2000. A measure of trauma was based on exposure to the 1999 earthquake. Dysregulation was based on 17 biomarkers (e.g., metabolic, inflammatory, neuroendocrine). Results— There were some small effects among men: chronic strain was associated with subsequent increases in dysregulation (standardized β=0.08, 95% CI = 0.01 to 0.20), particularly inflammation; life events were also associated with increased inflammation (β=0.10, CI = 0.01 to 0.26). There were no significant effects in women. Conclusions— We found weak evidence that stress burden is associated with changes in dysregulation.
Publication Date: Aug-2013
Electronic Publication Date: 23-Mar-2013
Citation: Glei, Dana A, Goldman, Noreen, Wu, Chih-Hsun, Weinstein, Maxine. "Does Exposure to Stressors Predict Changes in Physiological Dysregulation?" Annals of Behavioral Medicine, (1), 46, 121 - 126, doi:10.1007/s12160-013-9485-7
DOI: doi:10.1007/s12160-013-9485-7
ISSN: 0883-6612
EISSN: 1532-4796
Pages: 121 - 126
Type of Material: Journal Article
Journal/Proceeding Title: Annals of Behavioral Medicine
Version: This is the author’s final manuscript. All rights reserved to author(s).

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