Does Exposure to Stressors Predict Changes in Physiological Dysregulation?

Abstract

Background— The allostatic load framework implies that cumulative exposure to stressors results in multi-system physiological dysregulation. Purpose— To investigate the effect of stress burden on subsequent changes (2000-2006) in physiological dysregulation. Methods— Data came from a population-based cohort study in Taiwan (n=521, aged 54+ in 2000, re-examined in 2006). Measures of stressful events and chronic strain were based on questions asked in 1996, 1999, and 2000. A measure of trauma was based on exposure to the 1999 earthquake. Dysregulation was based on 17 biomarkers (e.g., metabolic, inflammatory, neuroendocrine). Results— There were some small effects among men: chronic strain was associated with subsequent increases in dysregulation (standardized β=0.08, 95% CI = 0.01 to 0.20), particularly inflammation; life events were also associated with increased inflammation (β=0.10, CI = 0.01 to 0.26). There were no significant effects in women. Conclusions— We found weak evidence that stress burden is associated with changes in dysregulation.