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Chapter 2: Data-Driven View of Disease Biology

Author(s): Greene, CS; Troyanskaya, Olga G.

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Abstract: Modern experimental strategies often generate genome-scale measurements of human tissues or cell lines in various physiological states. Investigators often use these datasets individually to help elucidate molecular mechanisms of human diseases. Here we discuss approaches that effectively weight and integrate hundreds of heterogeneous datasets to gene-gene networks that focus on a specific process or disease. Diverse and systematic genome-scale measurements provide such approaches both a great deal of power and a number of challenges. We discuss some such challenges as well as methods to address them. We also raise important considerations for the assessment and evaluation of such approaches. When carefully applied, these integrative data-driven methods can make novel high-quality predictions that can transform our understanding of the molecular-basis of human disease.
Publication Date: 27-Dec-2012
Electronic Publication Date: 27-Dec-2012
Citation: Greene, CS, Troyanskaya, OG. (2012). Chapter 2: Data-Driven View of Disease Biology. PLoS Computational Biology, 8 (10.1371/journal.pcbi.1002816
DOI: doi:10.1371/journal.pcbi.1002816
Type of Material: Journal Article
Journal/Proceeding Title: PLoS Computational Biology
Version: Final published version. Article is made available in OAR by the publisher's permission or policy.

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