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Digital Museum of Retinal Ganglion Cells with Dense Anatomy and Physiology

Author(s): Bae, J Alexander; Mu, Shang; Kim, Jinseop S; Turner, Nicholas L; Tartavull, Ignacio; et al

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Abstract: When 3D electron microscopy and calcium imaging are used to investigate the structure and function of neural circuits, the resulting datasets pose new challenges of visualization and interpretation. Here, we present a new kind of digital resource that encompasses almost 400 ganglion cells from a single patch of mouse retina. An online “museum” provides a 3D interactive view of each cell’s anatomy, as well as graphs of its visual responses. The resource reveals two aspects of the retina’s inner plexiform layer: an arbor segregation principle governing structure along the light axis and a density conservation principle governing structure in the tangential plane. Structure is related to visual function; ganglion cells with arbors near the layer of ganglion cell somas are more sustained in their visual responses on average. Our methods are potentially applicable to dense maps of neuronal anatomy and physiology in other parts of the nervous system.
Publication Date: 2018
Citation: Bae, J. Alexander, Shang Mu, Jinseop S. Kim, Nicholas L. Turner, Ignacio Tartavull, Nico Kemnitz, Chris S. Jordan, Alex D Norton, William M. Silversmith, Rachel Prentki, Marissa Sorek, Celia David, Devon L. Jones, Doug Bland, Amy L.R. Sterling, Jungman Park, Kevin L. Briggman, H. Sebastian Seung, and Eyewirers. "Digital museum of retinal ganglion cells with dense anatomy and physiology." Cell 173, no. 5 (2018): 1293-1306.e19. doi:10.1016/j.cell.2018.04.040
DOI: 10.1016/j.cell.2018.04.040
ISSN: 0092-8674
EISSN: 1097-4172
Pages: 1293 - 1306.e19
Language: eng
Type of Material: Journal Article
Journal/Proceeding Title: Cell
Version: Author's manuscript
Notes: Supplemental Information:

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