Skip to main content

Invasion Dynamics of Teratogenic Infections in Light of Rubella Control: Implications for Zika Virus

Author(s): Metcalf, C. Jessica E.; Barrett, Alan

Download
To refer to this page use: http://arks.princeton.edu/ark:/88435/pr11462
Abstract: Introduction: The greatest burden for a subset of pathogens is associated with infection during pregnancy. Evidence for teratogenic effects of Zika Virus have highlighted the importance of understanding the epidemiology of such pathogens. Rubella is perhaps the most classic example, and there is much to be learned from the long history of modelling associated with this virus. Methods: We extended an existing framework for modeling age-specific dynamics of rubella to illustrate how the body of knowledge of rubella dynamics informs the dynamics of teratogenic infections more broadly, and particularly the impact of control on such infections in different transmission settings. Results: During invasion, the burden in women of childbearing age is expected to peak, but then fall to low levels before eventually levelling out. Importantly, as illustrated by rubella dynamics, there is potential for a paradoxical effect, where inadequate control efforts can increase the burden. Conclusions: Drawing on the existing body of work on rubella dynamics highlights key knowledge gaps for understanding the risks associated with Zika Virus. The magnitude and impacts of sterilizing immunity, plus antigenic maps measuring cross-protection with other flaviviruses, and the magnitude of transmission, as well as likely impact of control efforts on transmission are likely to be key variables for robust inference into the outcome of management efforts for Zika Virus.
Electronic Publication Date: 2016
Citation: Metcalf, C. Jessica E., Barrett, Alan. (2016). Invasion Dynamics of Teratogenic Infections in Light of Rubella Control: Implications for Zika Virus. PLoS Currents, 10.1371/currents.outbreaks.873427b89ab9c75eb90c8ddb8d8c7c90
DOI: doi:10.1371/currents.outbreaks.873427b89ab9c75eb90c8ddb8d8c7c90
EISSN: 2157-3999
Type of Material: Journal Article
Journal/Proceeding Title: PLoS Currents
Version: Final published version. This is an open access article.



Items in OAR@Princeton are protected by copyright, with all rights reserved, unless otherwise indicated.