Skip to main content

A Neural Basis for Developmental Topographic Disorientation

Author(s): Kim, Jiye G.; Aminoff, Elissa M.; Kastner, Sabine; Behrmann, Marlene

Download
To refer to this page use: http://arks.princeton.edu/ark:/88435/pr1zx7h
Abstract: Developmental topographic disorientation (DTD) is a life-long condition in which affected individuals are severely impaired in navigating around their environment. Individuals with DTD have no apparent structural brain damage on conventional imaging and the neural mechanisms underlying DTD are currently unknown. Using functional and diffusion tensor imaging, we present a comprehensive neuroimaging study of an individual, J.N., with well defined DTD. J.N. has intact scene-selective responses in the parahippocampal place area (PPA), transverse occipital sulcus, and retrosplenial cortex (RSC), key regions associated with scene perception and navigation. However, detailed fMRI studies probing selective tuning properties of these regions, as well as functional connectivity, suggest that J.N.'s RSC has an atypical response profile and an atypical functional coupling to PPA compared with human controls. This deviant functional profile of RSC is not due to compromised structural connectivity. This comprehensive examination suggests that the RSC may play a key role in navigation-related processing and that an alteration of the RSC's functional properties may serve as the neural basis for DTD.
Publication Date: 16-Sep-2015
Electronic Publication Date: 16-Sep-2015
Citation: Kim, JG, Aminoff, EM, Kastner, S, Behrmann, M. (2015). A Neural Basis for Developmental Topographic Disorientation. Journal of Neuroscience, 35 (37), 12954 - 12969. doi:10.1523/JNEUROSCI.0640-15.2015
DOI: doi:10.1523/JNEUROSCI.0640-15.2015
ISSN: 0270-6474
EISSN: 1529-2401
Pages: 12954 - 12969
Type of Material: Journal Article
Journal/Proceeding Title: Journal of Neuroscience
Version: Final published version. Article is made available in OAR by the publisher's permission or policy.



Items in OAR@Princeton are protected by copyright, with all rights reserved, unless otherwise indicated.