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A Neural Basis for Developmental Topographic Disorientation

Author(s): Kim, Jiye G.; Aminoff, Elissa M.; Kastner, Sabine; Behrmann, Marlene

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dc.contributor.authorKim, Jiye G.-
dc.contributor.authorAminoff, Elissa M.-
dc.contributor.authorKastner, Sabine-
dc.contributor.authorBehrmann, Marlene-
dc.identifier.citationKim, JG, Aminoff, EM, Kastner, S, Behrmann, M. (2015). A Neural Basis for Developmental Topographic Disorientation. Journal of Neuroscience, 35 (37), 12954 - 12969. doi:10.1523/JNEUROSCI.0640-15.2015en_US
dc.description.abstractDevelopmental topographic disorientation (DTD) is a life-long condition in which affected individuals are severely impaired in navigating around their environment. Individuals with DTD have no apparent structural brain damage on conventional imaging and the neural mechanisms underlying DTD are currently unknown. Using functional and diffusion tensor imaging, we present a comprehensive neuroimaging study of an individual, J.N., with well defined DTD. J.N. has intact scene-selective responses in the parahippocampal place area (PPA), transverse occipital sulcus, and retrosplenial cortex (RSC), key regions associated with scene perception and navigation. However, detailed fMRI studies probing selective tuning properties of these regions, as well as functional connectivity, suggest that J.N.'s RSC has an atypical response profile and an atypical functional coupling to PPA compared with human controls. This deviant functional profile of RSC is not due to compromised structural connectivity. This comprehensive examination suggests that the RSC may play a key role in navigation-related processing and that an alteration of the RSC's functional properties may serve as the neural basis for DTD.en_US
dc.format.extent12954 - 12969en_US
dc.relation.ispartofJournal of Neuroscienceen_US
dc.rightsFinal published version. Article is made available in OAR by the publisher's permission or policy.en_US
dc.titleA Neural Basis for Developmental Topographic Disorientationen_US
dc.typeJournal Articleen_US

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