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Evolution and morphology of microenvironment-enhanced malignancy of three-dimensional invasive solid tumors

Author(s): Jiao, Yang; Torquato, Salvatore

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dc.contributor.authorJiao, Yang-
dc.contributor.authorTorquato, Salvatore-
dc.date.accessioned2022-01-25T14:57:08Z-
dc.date.available2022-01-25T14:57:08Z-
dc.date.issued2013-05en_US
dc.identifier.citationJiao, Yang, Torquato, Salvatore. (2013). Evolution and morphology of microenvironment-enhanced malignancy of three-dimensional invasive solid tumors. Physical Review E, 87 (5), 10.1103/PhysRevE.87.052707en_US
dc.identifier.issn1539-3755-
dc.identifier.urihttp://arks.princeton.edu/ark:/88435/pr1zp3w03d-
dc.description.abstractThe emergence of invasive and metastatic behavior in malignant tumors can often lead to fatal outcomes for patients. The collective malignant tumor behavior resulting from the complex tumor-host interactions and the interactions between the tumor cells is currently poorly understood. In this paper, we employ a cellular automaton (CA) model to investigate microenvironment-enhanced malignant behaviors and morphologies of in vitro avascular invasive solid tumors in three dimensions. Our CA model incorporates a variety of microscopicscale tumor-host interactions, including the degradation of the extracellular matrix by the malignant cells, nutrient-driven cell migration, pressure buildup due to the deformation of the microenvironment by the growing tumor, and its effect on the local tumor-host interface stability. Moreover, the effects of cell-cell adhesion on tumor growth are explicitly taken into account. Specifically, we find that while strong cell-cell adhesion can suppress the invasive behavior of the tumors growing in soft microenvironments, cancer malignancy can be significantly enhanced by harsh microenvironmental conditions, such as exposure to high pressure levels. We infer from the simulation results a qualitative phase diagram that characterizes the expected malignant behavior of invasive solid tumors in terms of two competing malignancy effects: the rigidity of the microenvironment and cell-cell adhesion. This diagram exhibits phase transitions between noninvasive and invasive behaviors. We also discuss the implications of our results for the diagnosis, prognosis, and treatment of malignant tumors.en_US
dc.format.extent052707-1 - 052707-10en_US
dc.language.isoen_USen_US
dc.relation.ispartofPhysical Review Een_US
dc.rightsFinal published version. Article is made available in OAR by the publisher's permission or policy.en_US
dc.titleEvolution and morphology of microenvironment-enhanced malignancy of three-dimensional invasive solid tumorsen_US
dc.typeJournal Articleen_US
dc.identifier.doidoi:10.1103/PhysRevE.87.052707-
dc.date.eissued2013-05-13en_US
dc.identifier.eissn1550-2376-
pu.type.symplectichttp://www.symplectic.co.uk/publications/atom-terms/1.0/journal-articleen_US

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