Ir(iii)-catalyzed: Ortho C-H alkylations of (hetero)aromatic aldehydes using alkyl boron reagents
Author(s): Chen, Xiao-Yang; Sorensen, Erik J.
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Full metadata record
DC Field | Value | Language |
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dc.contributor.author | Chen, Xiao-Yang | - |
dc.contributor.author | Sorensen, Erik J. | - |
dc.date.accessioned | 2020-10-30T19:05:21Z | - |
dc.date.available | 2020-10-30T19:05:21Z | - |
dc.date.issued | 2018-03-01 | en_US |
dc.identifier.citation | Chen, X.Y., Sorensen, E.J. (2018). Ir(iii)-catalyzed: Ortho C-H alkylations of (hetero)aromatic aldehydes using alkyl boron reagents. Chemical Science, 9 (48), 8951 - 8956. doi:10.1039/c8sc03606c | en_US |
dc.identifier.issn | 2041-6520 | - |
dc.identifier.uri | http://arks.princeton.edu/ark:/88435/pr1zj7b | - |
dc.description | Volume 9, Issue 48, 2018, Pages 8951-8956.First published on 3rd October 2018. | en_US |
dc.description.abstract | © 2018 The Royal Society of Chemistry. Transition-metal-catalyzed C-H alkylation reactions directed by aldehydes or ketones have been largely restricted to electronically activated alkenes. Herein, we report a general protocol for the Ir(iii)-catalyzed ortho C-H alkylations of (hetero)aromatic aldehydes using alkyl boron reagents as the coupling partner. Featuring aniline as an inexpensive catalytic ligand, the method was compatible with a wide variety of benzaldehydes, heterocyclic aldehydes, potassium alkyltrifluoroborates as well as a few α,β-unsaturated aldehydes. An X-ray crystal structure of a benzaldehyde ortho C-H iridation intermediate was also successfully obtained. | en_US |
dc.format.extent | 9.48: 8951 - 8956 | en_US |
dc.language.iso | en | en_US |
dc.relation.ispartof | Chemical Science | en_US |
dc.rights | Final published version. This is an open access article. | en_US |
dc.title | Ir(iii)-catalyzed: Ortho C-H alkylations of (hetero)aromatic aldehydes using alkyl boron reagents | en_US |
dc.type | Journal Article | en_US |
dc.identifier.doi | doi:10.1039/c8sc03606c | - |
dc.identifier.eissn | 2041-6539 | - |
pu.type.symplectic | http://www.symplectic.co.uk/publications/atom-terms/1.0/journal-article | en_US |
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