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Protein folding and de novo protein design for biotechnological applications

Author(s): Khoury, George A; Smadbeck, James; Kieslich, Chris A; Floudas, Christodoulos A

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Abstract: In the postgenomic era, the medical/biological fields are advancing faster than ever. However, before the power of full-genome sequencing can be fully realized, the connection between amino acid sequence and protein structure, known as the protein folding problem, needs to be elucidated. The protein folding problem remains elusive, with significant difficulties still arising when modeling amino acid sequences lacking an identifiable template. Understanding protein folding will allow for unforeseen advances in protein design; often referred to as the inverse protein folding problem. Despite challenges in protein folding, de novo protein design has recently demonstrated significant success via computational techniques. We review advances and challenges in protein structure prediction and de novo protein design, and highlight their interplay in successful biotechnological applications.
Publication Date: Feb-2014
Citation: Khoury, George A., James Smadbeck, Chris A. Kieslich, and Christodoulos A. Floudas. "Protein folding and de novo protein design for biotechnological applications." Trends in Biotechnology 32, no. 2 (2014): 99-109. doi:10.1016/j.tibtech.2013.10.008
DOI: doi:10.1016/j.tibtech.2013.10.008
ISSN: 0167-7799
EISSN: 1879-3096
Pages: 99 - 109
Type of Material: Journal Article
Journal/Proceeding Title: Trends in Biotechnology
Version: Author's manuscript

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