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Responsive foams for nanoparticle delivery

Author(s): Tang, C; Xiao, E; Sinko, PJ; Szekely, Z; Prud homme, Robert K

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Abstract: We have developed responsive foam systems for nanoparticle delivery. The foams are easy to make, stable at room temperature, and can be engineered to break in response to temperature or moisture. Temperature-responsive foams are based on the phase transition of long chain alcohols and could be produced using medical grade nitrous oxide as a propellant. These temperature-sensitive foams could be used for polyacrylic acid (PAA)-based nanoparticle delivery. We also discuss moisture-responsive foams made with soap pump dispensers. Polyethylene glycol (PEG)-based nanoparticles or PMMA latex nanoparticles were loaded into Tween 20 foams and the particle size was not affected by the foam formulation or foam break. Using biocompatible detergents, we anticipate this will be a versatile and simple approach to producing foams for nanoparticle delivery with many potential pharmaceutical and personal care applications.
Publication Date: 2015
Citation: Tang, C, Xiao, E, Sinko, PJ, Szekely, Z, Prud homme, RK. (2015). Responsive foams for nanoparticle delivery. Colloids and Surfaces B: Biointerfaces, 133 (81 - 87. doi:10.1016/j.colsurfb.2015.05.038
DOI: doi:10.1016/j.colsurfb.2015.05.038
Pages: 81 - 87
Type of Material: Journal Article
Journal/Proceeding Title: Colloids and Surfaces B: Biointerfaces
Version: Author's manuscript

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