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Toward a mild dehydroformylation using base-metal catalysis

Author(s): Abrams, Dylan J.; West, Julian G.; Sorensen, Erik J.

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Abstract: Dehydroformylation, or the reaction of aldehydes to produce alkenes, hydrogen gas, and carbon monoxide, is a powerful transformation that is underdeveloped despite the high industrial importance of the reverse reaction, hydroformylation. Interestingly, nature routinely performs a related transformation, oxidative dehydroformylation, in the biosynthesis of cholesterol and related sterols under mild conditions using base-metal catalysts. In contrast, chemists have recently developed a non-oxidative dehydroformylation method; however, it requires high temperatures and a precious-metal catalyst. Careful study of both approaches has informed our efforts to design a base-metal catalyzed, mild dehydroformylation method that incorporates benefits from each while avoiding several of their respective disadvantages. Importantly, we show that cooperative base metal catalysis presents a powerful, mechanistically unique approach to reactions which are difficult to achieve using conventional catalyst design.
Publication Date: 2017
Electronic Publication Date: 2017
Citation: Abrams, Dylan J, West, Julian G, Sorensen, Erik J. (2017). Toward a mild dehydroformylation using base-metal catalysis. Chemical Science, 8 (3), 1954 - 1959. doi:10.1039/C6SC04607J
DOI: doi:10.1039/C6SC04607J
ISSN: 2041-6520
EISSN: 2041-6539
Pages: 1954 - 1959
Type of Material: Journal Article
Journal/Proceeding Title: Chemical Science
Version: Final published version. This is an open access article.

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