A Mathematical Model for Early HBV and -HDV Kinetics during Anti-HDV Treatment

Author(s): Zakh, Rami; Churkin, Alexander; Bietsch, William; Lachiany, Menachem; Cotler, Scott J; et al

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Abstract:	Hepatitis delta virus (HDV) is an infectious subviral agent that can only propagate in people infected with hepatitis B virus (HBV). HDV/HBV infection is considered to be the most severe form of chronic viral hepatitis. In this contribution, a mathematical model for the interplay between HDV and HBV under anti-HDV treatment is presented. Previous models were not designed to account for the observation that HBV rises when HDV declines with HDV-specific therapy. In the simple model presented here, HDV and HBV kinetics are coupled, giving rise to an improved viral kinetic model that simulates the early interplay of HDV and HBV during anti-HDV therapy.
Publication Date:	20-Dec-2021
Citation:	Zakh, R.; Churkin, A.; Bietsch, W.; Lachiany, M.; Cotler, S.J.; Ploss, A.; Dahari, H.; Barash, D. A Mathematical Model for Early HBV and -HDV Kinetics during Anti-HDV Treatment. Mathematics 2021, 9, 3323. https://doi.org/10.3390/math9243323
DOI:	doi:10.3390/math9243323
EISSN:	2227-7390
Keywords:	hepatitis delta virus; HDV-HBV coinfection; viral kinetic models
Language:	en
Type of Material:	Journal Article
Journal/Proceeding Title:	Mathematics
Version:	Final published version. This is an open access article.