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A Mathematical Model for Early HBV and -HDV Kinetics during Anti-HDV Treatment

Author(s): Zakh, Rami; Churkin, Alexander; Bietsch, William; Lachiany, Menachem; Cotler, Scott J; et al

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dc.contributor.authorZakh, Rami-
dc.contributor.authorChurkin, Alexander-
dc.contributor.authorBietsch, William-
dc.contributor.authorLachiany, Menachem-
dc.contributor.authorCotler, Scott J-
dc.contributor.authorPloss, Alexander-
dc.contributor.authorDahari, Harel-
dc.contributor.authorBarash, Danny-
dc.date.accessioned2023-12-13T22:37:07Z-
dc.date.available2023-12-13T22:37:07Z-
dc.date.issued2021-12-20en_US
dc.identifier.citationZakh, R.; Churkin, A.; Bietsch, W.; Lachiany, M.; Cotler, S.J.; Ploss, A.; Dahari, H.; Barash, D. A Mathematical Model for Early HBV and -HDV Kinetics during Anti-HDV Treatment. Mathematics 2021, 9, 3323. https://doi.org/10.3390/math9243323en_US
dc.identifier.urihttp://arks.princeton.edu/ark:/88435/pr1sq8qh6p-
dc.description.abstractHepatitis delta virus (HDV) is an infectious subviral agent that can only propagate in people infected with hepatitis B virus (HBV). HDV/HBV infection is considered to be the most severe form of chronic viral hepatitis. In this contribution, a mathematical model for the interplay between HDV and HBV under anti-HDV treatment is presented. Previous models were not designed to account for the observation that HBV rises when HDV declines with HDV-specific therapy. In the simple model presented here, HDV and HBV kinetics are coupled, giving rise to an improved viral kinetic model that simulates the early interplay of HDV and HBV during anti-HDV therapy.en_US
dc.languageenen_US
dc.language.isoen_USen_US
dc.relation.ispartofMathematicsen_US
dc.rightsFinal published version. This is an open access article.en_US
dc.subjecthepatitis delta virus; HDV-HBV coinfection; viral kinetic modelsen_US
dc.titleA Mathematical Model for Early HBV and -HDV Kinetics during Anti-HDV Treatmenten_US
dc.typeJournal Articleen_US
dc.identifier.doidoi:10.3390/math9243323-
dc.identifier.eissn2227-7390-
pu.type.symplectichttp://www.symplectic.co.uk/publications/atom-terms/1.0/journal-articleen_US

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