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Deubiquitinase USP20 promotes breast cancer metastasis by stabilizing SNAI2

Author(s): Li, Wenyang; Shen, Minhong; Jiang, Yi-Zhou; Zhang, Ruina; Zheng, Hanqiu; et al

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Abstract: SNAI2/SLUG, a metastasis-promoting transcription factor, is a labile protein that is degraded through the ubiquitin proteasome degradation system. Here, we conducted comprehensive gain- and loss-of-function screens using a human DUB cDNA library of 65 genes and an siRNA library of 98 genes, and identified USP20 as a deubiquitinase (DUB) that regulates SNAI2 ubiquitination and stability. Further investigation of USP20 demonstrated its function in promoting migration, invasion, and metastasis of breast cancer. USP20 positively correlates with SNAI2 protein level in breast tumor samples, and higher USP20 expression is associated with poor prognosis in ER<sup>-</sup> breast cancer patients.
Publication Date: Oct-2020
Citation: Li, Wenyang, Shen, Minhong, Jiang, Yi-Zhou, Zhang, Ruina, Zheng, Hanqiu, Wei, Yong, Shao, Zhi-Ming, Kang, Yibin. (2020). Deubiquitinase USP20 promotes breast cancer metastasis by stabilizing SNAI2. Genes & development, 34 (19-20), 1310 - 1315. doi:10.1101/gad.339804.120
DOI: doi:10.1101/gad.339804.120
ISSN: 0890-9369
EISSN: 1549-5477
Pages: 1310 - 1315
Language: eng
Type of Material: Journal Article
Journal/Proceeding Title: Genes & Development
Version: Final published version. This is an open access article.

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