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Deubiquitinase USP20 promotes breast cancer metastasis by stabilizing SNAI2

Author(s): Li, Wenyang; Shen, Minhong; Jiang, Yi-Zhou; Zhang, Ruina; Zheng, Hanqiu; et al

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DC FieldValueLanguage
dc.contributor.authorLi, Wenyang-
dc.contributor.authorShen, Minhong-
dc.contributor.authorJiang, Yi-Zhou-
dc.contributor.authorZhang, Ruina-
dc.contributor.authorZheng, Hanqiu-
dc.contributor.authorWei, Yong-
dc.contributor.authorShao, Zhi-Ming-
dc.contributor.authorKang, Yibin-
dc.date.accessioned2022-01-25T14:52:31Z-
dc.date.available2022-01-25T14:52:31Z-
dc.date.issued2020-10en_US
dc.identifier.citationLi, Wenyang, Shen, Minhong, Jiang, Yi-Zhou, Zhang, Ruina, Zheng, Hanqiu, Wei, Yong, Shao, Zhi-Ming, Kang, Yibin. (2020). Deubiquitinase USP20 promotes breast cancer metastasis by stabilizing SNAI2. Genes & development, 34 (19-20), 1310 - 1315. doi:10.1101/gad.339804.120en_US
dc.identifier.issn0890-9369-
dc.identifier.urihttp://arks.princeton.edu/ark:/88435/pr1qn5z99s-
dc.description.abstractSNAI2/SLUG, a metastasis-promoting transcription factor, is a labile protein that is degraded through the ubiquitin proteasome degradation system. Here, we conducted comprehensive gain- and loss-of-function screens using a human DUB cDNA library of 65 genes and an siRNA library of 98 genes, and identified USP20 as a deubiquitinase (DUB) that regulates SNAI2 ubiquitination and stability. Further investigation of USP20 demonstrated its function in promoting migration, invasion, and metastasis of breast cancer. USP20 positively correlates with SNAI2 protein level in breast tumor samples, and higher USP20 expression is associated with poor prognosis in ER<sup>-</sup> breast cancer patients.en_US
dc.format.extent1310 - 1315en_US
dc.languageengen_US
dc.language.isoen_USen_US
dc.relation.ispartofGenes & Developmenten_US
dc.rightsFinal published version. This is an open access article.en_US
dc.titleDeubiquitinase USP20 promotes breast cancer metastasis by stabilizing SNAI2en_US
dc.typeJournal Articleen_US
dc.identifier.doidoi:10.1101/gad.339804.120-
dc.identifier.eissn1549-5477-
pu.type.symplectichttp://www.symplectic.co.uk/publications/atom-terms/1.0/journal-articleen_US

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